Anti-inflammatory Metabolites from Chaetomium nigricolor

Min Jee Kim, Dong Cheol Kim, Jaeyoung Kwon, Seung Mok Ryu, Haeun Kwon, Yuanqiang Guo, Seung Beom Hong, Youn Chul Kim, Hyuncheol Oh, Dongho Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Twelve metabolites were obtained from the culture media of Chaetomium nigricolor, including a new furan derivative, methyl succinyl Sumiki's acid (1), and two new atropisomers of the previously reported bis-naphtho-γ-pyrones, (aS)-asperpyrone A and (aS)-fonsecinone A (2 and 3). The structures were elucidated by spectroscopic, chemical, and chiroptical techniques. Compounds 2 and 3 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compound 2 was found to inhibit nuclear factor-kappa B and c-Jun N-terminal kinase activation, in turn suppressing pro-inflammatory mediators and cytokines including nitric oxide, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12.

Original languageEnglish
Pages (from-to)881-887
Number of pages7
JournalJournal of Natural Products
Volume83
Issue number4
DOIs
Publication statusPublished - 2020 Apr 24

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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