Anti-inflammatory Metabolites from Chaetomium nigricolor

Min Jee Kim, Dong Cheol Kim, Jaeyoung Kwon, Seung Mok Ryu, Haeun Kwon, Yuanqiang Guo, Seung Beom Hong, Youn Chul Kim, Hyuncheol Oh, Dongho Lee

Research output: Contribution to journalArticle

Abstract

Twelve metabolites were obtained from the culture media of Chaetomium nigricolor, including a new furan derivative, methyl succinyl Sumiki's acid (1), and two new atropisomers of the previously reported bis-naphtho-γ-pyrones, (aS)-asperpyrone A and (aS)-fonsecinone A (2 and 3). The structures were elucidated by spectroscopic, chemical, and chiroptical techniques. Compounds 2 and 3 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compound 2 was found to inhibit nuclear factor-kappa B and c-Jun N-terminal kinase activation, in turn suppressing pro-inflammatory mediators and cytokines including nitric oxide, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12.

Original languageEnglish
JournalJournal of Natural Products
DOIs
Publication statusAccepted/In press - 2020 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Kim, M. J., Kim, D. C., Kwon, J., Ryu, S. M., Kwon, H., Guo, Y., Hong, S. B., Kim, Y. C., Oh, H., & Lee, D. (Accepted/In press). Anti-inflammatory Metabolites from Chaetomium nigricolor. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.9b00560