Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha

Bangjian Dong, Xueyuan Yang, Wenpei Liu, Lijun An, Xuke Zhang, Muhetaer Tuerhong, Qing Du, Chunyan Wang, Munira Abudukeremu, Jing Xu, Dongho Lee, Ling Shuai, Namrita Lall, Yuanqiang Guo

Research output: Contribution to journalArticle

Abstract

Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effects with IC50 values of 20.2, 45.5, 34.0, 27.0, 45.0, and 25.8 μM, respectively. The more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as their binding interactions with the two proteins.

Original languageEnglish
JournalJournal of Natural Products
DOIs
Publication statusAccepted/In press - 2020 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Dong, B., Yang, X., Liu, W., An, L., Zhang, X., Tuerhong, M., Du, Q., Wang, C., Abudukeremu, M., Xu, J., Lee, D., Shuai, L., Lall, N., & Guo, Y. (Accepted/In press). Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.9b00629