Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha

Bangjian Dong; Xueyuan Yang; Wenpei Liu; Lijun An; Xuke Zhang; Muhetaer Tuerhong; Qing Du; Chunyan Wang; Munira Abudukeremu; Jing Xu; Dongho Lee; Ling Shuai; Namrita Lall; Yuanqiang Guo

doi:10.1021/acs.jnatprod.9b00629

Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha

Bangjian Dong, Xueyuan Yang, Wenpei Liu, Lijun An, Xuke Zhang, Muhetaer Tuerhong, Qing Du, Chunyan Wang, Munira Abudukeremu, Jing Xu, Dongho Lee, Ling Shuai, Namrita Lall, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article

Abstract

Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effects with IC₅₀ values of 20.2, 45.5, 34.0, 27.0, 45.0, and 25.8 μM, respectively. The more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as their binding interactions with the two proteins.

Original language	English
Journal	Journal of Natural Products
DOIs	https://doi.org/10.1021/acs.jnatprod.9b00629
Publication status	Accepted/In press - 2020 Jan 1

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/acs.jnatprod.9b00629

Cite this

Dong, B., Yang, X., Liu, W., An, L., Zhang, X., Tuerhong, M., Du, Q., Wang, C., Abudukeremu, M., Xu, J., Lee, D., Shuai, L., Lall, N., & Guo, Y. (Accepted/In press). Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.9b00629

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title = "Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha",

abstract = "Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effects with IC50 values of 20.2, 45.5, 34.0, 27.0, 45.0, and 25.8 μM, respectively. The more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as their binding interactions with the two proteins.",

author = "Bangjian Dong and Xueyuan Yang and Wenpei Liu and Lijun An and Xuke Zhang and Muhetaer Tuerhong and Qing Du and Chunyan Wang and Munira Abudukeremu and Jing Xu and Dongho Lee and Ling Shuai and Namrita Lall and Yuanqiang Guo",

year = "2020",

month = jan,

day = "1",

doi = "10.1021/acs.jnatprod.9b00629",

language = "English",

journal = "Journal of Natural Products",

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publisher = "American Chemical Society",

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T1 - Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha

AU - Dong, Bangjian

AU - Yang, Xueyuan

AU - Liu, Wenpei

AU - An, Lijun

AU - Zhang, Xuke

AU - Tuerhong, Muhetaer

AU - Du, Qing

AU - Wang, Chunyan

AU - Abudukeremu, Munira

AU - Xu, Jing

AU - Lee, Dongho

AU - Shuai, Ling

AU - Lall, Namrita

AU - Guo, Yuanqiang

PY - 2020/1/1

Y1 - 2020/1/1

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AB - Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effects with IC50 values of 20.2, 45.5, 34.0, 27.0, 45.0, and 25.8 μM, respectively. The more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as their binding interactions with the two proteins.

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