TY - JOUR
T1 - Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha
AU - Dong, Bangjian
AU - Yang, Xueyuan
AU - Liu, Wenpei
AU - An, Lijun
AU - Zhang, Xuke
AU - Tuerhong, Muhetaer
AU - Du, Qing
AU - Wang, Chunyan
AU - Abudukeremu, Munira
AU - Xu, Jing
AU - Lee, Dongho
AU - Shuai, Ling
AU - Lall, Namrita
AU - Guo, Yuanqiang
N1 - Funding Information:
This research was supported financially by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107 and U1801288), Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin (No. 19JCYBJC28100), and State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. GTZK201902).
Publisher Copyright:
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy.
PY - 2020/4/24
Y1 - 2020/4/24
N2 - Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effects with IC50 values of 20.2, 45.5, 34.0, 27.0, 45.0, and 25.8 μM, respectively. The more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as their binding interactions with the two proteins.
AB - Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effects with IC50 values of 20.2, 45.5, 34.0, 27.0, 45.0, and 25.8 μM, respectively. The more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as their binding interactions with the two proteins.
UR - http://www.scopus.com/inward/record.url?scp=85082761118&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.9b00629
DO - 10.1021/acs.jnatprod.9b00629
M3 - Article
C2 - 32216313
AN - SCOPUS:85082761118
VL - 83
SP - 894
EP - 904
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 4
ER -