Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense

Jaeyoung Kwon, Min Jee Kim, Dong Cheol Kim, Haeun Kwon, Seung Mok Ryu, Sang Hee Shim, Yuanqiang Guo, Seung Beom Hong, Joung Han Yim, Youn Chul Kim, Hyuncheol Oh, Dongho Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation is a vital process that maintains tissue homeostasis. However, it is widely known that uncontrolled inflammation can contribute to the development of various diseases. This study aimed to discover anti-inflammatory metabolites from Penicillium bialowiezense. Seven spiroditerpenoids, including two new compounds, breviones P and Q (1 and 2), were isolated and characterized by various spectroscopic and spectrometric methods. All isolated compounds were initially tested for their inhibitory effects against lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages. Of these, brevione A (3) exhibited this activity with a half-maximal inhibitory concentration value of 9.5 μM. Further mechanistic studies demonstrated that 3 could suppress the expression of pro-inflammatory cytokines and mediators, such as NO, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12 by inhibiting the activation of nuclear factor-kappa B and c-Jun N-terminal kinase.

Original languageEnglish
Article number105012
JournalBioorganic Chemistry
Volume113
DOIs
Publication statusPublished - 2021 Aug

Keywords

  • Anti-inflammatory effect
  • Brevione
  • Penicillium bialowiezense
  • Spiroditerpenoid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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