Anti-integrin therapy for inflammatory bowel disease

Sung Chul Park, Yoon Tae Jeen

    Research output: Contribution to journalReview articlepeer-review

    37 Citations (Scopus)

    Abstract

    In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Antiintegrin therapy blocks the action of integrin on the surface of circulating immune cells and endothelial cell adhesion molecules, thereby inhibiting the interactions between leukocytes and intestinal blood vessels. Natalizumab, which acts on α4integrin, was the first such drug to be approved for Crohn’s disease, but its use is limited due to the risk of progressive multifocal leukoencephalopathy. Vedolizumab produces few systemic adverse effects because it acts on guttrophic α4β7 integrin, and has been approved and is being used to treat IBD. Currently, several antiintegrin drugs, including etrolizumab, which acts on β7integrin, and PF00547569, which targets mucosal addressin cell adhesion molecule1, are undergoing clinical trials and the results are being closely watched.

    Original languageEnglish
    Pages (from-to)1868-1880
    Number of pages13
    JournalWorld journal of gastroenterology
    Volume24
    Issue number17
    DOIs
    Publication statusPublished - 2018 May 7

    Keywords

    • AJM300
    • Abrilumab
    • Crohn’s disease
    • Etrolizumab
    • Inflammatory bowel disease
    • Integrin
    • Natalizumab
    • PF00547659
    • Ulcerative colitis
    • Vedolizumab

    ASJC Scopus subject areas

    • Gastroenterology

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