Anti-obesity effects of (-)-epigallocathchin-3-gallate and its molecular mechanism

Cheol Heui Yun, Gi Rak Kim, Min Ji Seo, Hyun-Seuk Moon, Chong Su Cho

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Development of obesity appears to be influenced by a complex array of genetic, metabolic, and neural frameworks, together with one's behavior, eating habit, and physical activity. The incidence of obesity is significantly increasing in virtually all societies of the world and causes important pathological consequences such as cardiovascular diseases and type 2 diabetes mellitus. Furthermore, rates of pediatric obesity have increased dramatically over the past decade resulting cardiovascular, metabolic, and hepatic complications. Since ancient times, green tea has been considered as a traditional medicine as a healthful beverage. Major components of green tea including epigallocathchin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG) and epicatechin (EC) have been received significant scientific attention and public awareness for its beneficial effects on prevention and therapeutic treatment of cardiovascular diseases and cancer. Anti-obesity effects of EGCG have been demonstrated in various in vitro and in vivo models showing that EGCG treatment could reduce food intake, glucose uptake, blood glucose level, and differentiation and growth activity of fat cells together with modulation of lipolytic and lipogenic activities. In these actions, large number of molecules including laminin receptor, fatty acid synthase, glucose-6-phosphate dehydrogenase, cyclin-dependent kinase 2, CCAAT/enhancer binding proteins, mitogen activated protein kinases, AMP-activated protein kinase, phosphatidylinositol-3-kinase, peroxisome proliferator activated receptor, and number of transcription factors including NF-kB were suggested to be involved. This review will focus on the effects of ECGC at molecular level in terms of (1) receptor recognition, (2) modulation of signaling pathways, (3) lipid metabolism and altering the lipogenic and lipolytic activities leading to metabolic changes and apoptosis, and (4) final outcome in vitro and in vivo.

Original languageEnglish
Title of host publicationHandbook of Green Tea and Health Research
PublisherNova Science Publishers, Inc.
Pages125-155
Number of pages31
ISBN (Print)9781607410454
Publication statusPublished - 2009 Feb 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Yun, C. H., Kim, G. R., Seo, M. J., Moon, H-S., & Cho, C. S. (2009). Anti-obesity effects of (-)-epigallocathchin-3-gallate and its molecular mechanism. In Handbook of Green Tea and Health Research (pp. 125-155). Nova Science Publishers, Inc..