Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet

Joo Yeon Kim, Mak Soon Lee, Sunyoon Jung, Hyunjin Joo, Chong Tai Kim, In-Hwan Kim, Sangjin Seo, Soojung Oh, Yangha Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods: The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor (PPAR)-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including PPAR-α, palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK) activity. In particular, PPAR-α, palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehy-drogenase in white adipose tissue.

Original languageEnglish
Pages (from-to)301-310
Number of pages10
JournalInternational Journal of Nanomedicine
Volume9
Issue number1
DOIs
Publication statusPublished - 2014 Jan 3

Fingerprint

High Fat Diet
Nutrition
Oils and fats
Rats
Obesity
Fats
Proteins
Peroxisome Proliferator-Activated Receptors
AMP-Activated Protein Kinases
Tissue
Glycerol
White Adipose Tissue
Phosphates
Genes
Fatty acids
Gene expression
Anti-Obesity Agents
Sterol Regulatory Element Binding Protein 1
Diet
Glycerolphosphate Dehydrogenase

Keywords

  • Amp-activated protein kinase
  • Anti-obesity
  • Gene expression
  • Nanoemulsion
  • Oleoresin capsicum
  • Rats

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Drug Discovery

Cite this

Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet. / Kim, Joo Yeon; Lee, Mak Soon; Jung, Sunyoon; Joo, Hyunjin; Kim, Chong Tai; Kim, In-Hwan; Seo, Sangjin; Oh, Soojung; Kim, Yangha.

In: International Journal of Nanomedicine, Vol. 9, No. 1, 03.01.2014, p. 301-310.

Research output: Contribution to journalArticle

Kim, Joo Yeon ; Lee, Mak Soon ; Jung, Sunyoon ; Joo, Hyunjin ; Kim, Chong Tai ; Kim, In-Hwan ; Seo, Sangjin ; Oh, Soojung ; Kim, Yangha. / Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet. In: International Journal of Nanomedicine. 2014 ; Vol. 9, No. 1. pp. 301-310.
@article{57b49e0d11714eeb83d9f1a7c2fc030c,
title = "Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet",
abstract = "Purpose: This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods: The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor (PPAR)-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including PPAR-α, palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK) activity. In particular, PPAR-α, palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehy-drogenase in white adipose tissue.",
keywords = "Amp-activated protein kinase, Anti-obesity, Gene expression, Nanoemulsion, Oleoresin capsicum, Rats",
author = "Kim, {Joo Yeon} and Lee, {Mak Soon} and Sunyoon Jung and Hyunjin Joo and Kim, {Chong Tai} and In-Hwan Kim and Sangjin Seo and Soojung Oh and Yangha Kim",
year = "2014",
month = "1",
day = "3",
doi = "10.2147/IJN.S52414",
language = "English",
volume = "9",
pages = "301--310",
journal = "International Journal of Nanomedicine",
issn = "1176-9114",
publisher = "Dove Medical Press Ltd.",
number = "1",

}

TY - JOUR

T1 - Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet

AU - Kim, Joo Yeon

AU - Lee, Mak Soon

AU - Jung, Sunyoon

AU - Joo, Hyunjin

AU - Kim, Chong Tai

AU - Kim, In-Hwan

AU - Seo, Sangjin

AU - Oh, Soojung

AU - Kim, Yangha

PY - 2014/1/3

Y1 - 2014/1/3

N2 - Purpose: This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods: The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor (PPAR)-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including PPAR-α, palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK) activity. In particular, PPAR-α, palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehy-drogenase in white adipose tissue.

AB - Purpose: This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods: The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor (PPAR)-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including PPAR-α, palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK) activity. In particular, PPAR-α, palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehy-drogenase in white adipose tissue.

KW - Amp-activated protein kinase

KW - Anti-obesity

KW - Gene expression

KW - Nanoemulsion

KW - Oleoresin capsicum

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=84891783028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891783028&partnerID=8YFLogxK

U2 - 10.2147/IJN.S52414

DO - 10.2147/IJN.S52414

M3 - Article

C2 - 24403834

AN - SCOPUS:84891783028

VL - 9

SP - 301

EP - 310

JO - International Journal of Nanomedicine

JF - International Journal of Nanomedicine

SN - 1176-9114

IS - 1

ER -