Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet

Joo Yeon Kim, Mak Soon Lee, Sunyoon Jung, Hyunjin Joo, Chong Tai Kim, In Hwan Kim, Sangjin Seo, Soojung Oh, Yangha Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods: The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor (PPAR)-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including PPAR-α, palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK) activity. In particular, PPAR-α, palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehy-drogenase in white adipose tissue.

Original languageEnglish
Pages (from-to)301-310
Number of pages10
JournalInternational Journal of Nanomedicine
Volume9
Issue number1
DOIs
Publication statusPublished - 2014 Jan 3

Keywords

  • Amp-activated protein kinase
  • Anti-obesity
  • Gene expression
  • Nanoemulsion
  • Oleoresin capsicum
  • Rats

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet'. Together they form a unique fingerprint.

Cite this