Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: Synthesis, characterization, and use in cancer imaging in vivo

Jinho Park, Mi Kyung Yu, Yong Yeon Jeong, Jin Woong Kim, Kwangyeol Lee, Vu Ngoc Phan, Sangyong Jon

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as T2-contrast agents for magnetic resonance imaging (MRI). Herein we develop various antibiofouling amphiphilic polymer-coated SPIONs using a one-step nanoemulsion method. This methodology yielded ultrasmall polymer-coated SPIONs, of average diameter less than 30 nm, which were stable under physiological conditions. In vitro cell cytotoxicity tests revealed that no SPION showed toxicity even at relatively high concentrations. In vivo MRI with Lewis lung carcinoma (LLC) tumor-bearing mice resulted in an approximately 30% T2 signal drop in tumor tissues, indicating that the SPIONs reached such tissues via passive targeting. In summary, the ultrasmall, stable, amphiphilic polymer-coated SPIONs can be used as MRI contrast agents for cancer imaging.

Original languageEnglish
Pages (from-to)6412-6417
Number of pages6
JournalJournal of Materials Chemistry
Volume19
Issue number35
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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