Antibiotic treatment of Mycobacterium abscessus lung disease: A retrospective analysis of 65 patients

Kyeongman Jeon, O. Jung Kwon, Yong Lee Nam, Bum Joon Kim, Yoon Hoh Kook, Seung Heon Lee, Kil Park Young, Ki Kim Chang, Won Jung Koh

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186 Citations (Scopus)

Abstract

Rationale: The optimal therapeutic regimen and duration of treatment for Mycobacterium abscessus lung disease is not well established. Objectives: To assess the efficacy of a standardized combination antibiotic therapy for the treatment of M. abscessus lung disease. Methods: Sixty-five patients (11 males, 55 females, median age 55 yr) with M. abscessus lung disease were treated with clarithromycin, ciprofloxacin, and doxycycline, together with an initial regimen of amikacin and cefoxitin for the first 4 weeks of hospitalization. Measurements and Main Results: Treatment response rates were 83% for symptoms and 74% for high-resolution computed tomography. Sputum conversion and maintenance of negative sputum cultures for more than 12 months was achieved in 38 (58%) patients. These rates were significantly lower in patients whose isolates were resistant to clarithromycin (17%, 2/12) compared with those whose isolates were susceptible or intermediate to clarithromycin (64%, 21/33; P = 0.007). Neutropenia and thrombocytopenia associated with cefoxitin developed in 33 (51%) and 4 (6%) patients, respectively. Drug-induced hepatotoxicity occurred in 10 (15%) patients. Because of these adverse reactions, cefoxitin was discontinued in 39 (60%) patients after treatment for a median of 22 days. Conclusions: Standardized combination antibiotic therapy was moderately effective in treating M. abscessus lung disease. However, frequent adverse reactions and the potential for long-duration hospitalization are important problems that remain to be solved.

Original languageEnglish
Pages (from-to)896-902
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume180
Issue number9
DOIs
Publication statusPublished - 2009 Nov 1
Externally publishedYes

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Keywords

  • Atypical mycobacteria
  • Lung diseases
  • Mycobacterium abscessus
  • Treatment outcome

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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