Anticariogenic Activity of Agarobiose and Agarooligosaccharides Derived from Red Macroalgae

Sora Yu, Eun Ju Yun, Dong Hyun Kim, So Young Park, Kyoung Heon Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

3,6-Anhydro-l-galactose (AHG) produced from agarose in red macroalgae was recently suggested as an anticariogenic sugar to replace widely used xylitol. However, the multi-step process for obtaining monomeric sugar AHG from agarose may be expensive. Generally, it is easier to obtain oligosaccharides than monosaccharides from polysaccharides. Therefore, a one-step process to obtain agarobiose (AB) from agarose was recently developed, and here, we suggest AB as a new anticariogenic agent, owing to its anticariogenic activity against Streptococcus mutans. Among AHG-containing oligosaccharides, AB, neoagarobiose (NAB), agarooligosaccharides (AOSs), and neoagarooligosaccharides (NAOSs), AB showed higher inhibitory activity than AOSs against the growth and lactic acid production of S. mutans; no such inhibitory activity was observed for NAB and NAOSs. This inhibitory effect of AB was comparable to the previously reported inhibitory activity of AHG against S. mutans. These results suggest that AB, which can be more economically and simply produced than AHG, may serve as an anticariogenic sugar.

Original languageEnglish
Pages (from-to)7297-7303
Number of pages7
JournalJournal of agricultural and food chemistry
Volume67
Issue number26
DOIs
Publication statusPublished - 2019 Jul 3

Fingerprint

Seaweed
galactose
macroalgae
Streptococcus mutans
Galactose
agarose
sugars
oligosaccharides
Sugars
Sepharose
xylitol
Oligosaccharides
monosaccharides
lactic acid
Xylitol
polysaccharides
neoagarobiose
Monosaccharides
Polysaccharides
Lactic Acid

Keywords

  • agar
  • agarobiose
  • agarooligosaccharides
  • agarose
  • anticariogenic
  • dental caries
  • red macroalgae

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Cite this

Anticariogenic Activity of Agarobiose and Agarooligosaccharides Derived from Red Macroalgae. / Yu, Sora; Yun, Eun Ju; Kim, Dong Hyun; Park, So Young; Kim, Kyoung Heon.

In: Journal of agricultural and food chemistry, Vol. 67, No. 26, 03.07.2019, p. 7297-7303.

Research output: Contribution to journalArticle

Yu, Sora ; Yun, Eun Ju ; Kim, Dong Hyun ; Park, So Young ; Kim, Kyoung Heon. / Anticariogenic Activity of Agarobiose and Agarooligosaccharides Derived from Red Macroalgae. In: Journal of agricultural and food chemistry. 2019 ; Vol. 67, No. 26. pp. 7297-7303.
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