Anticoagulant Activity of Sulfoalkyl Derivatives of Curdlan

Kyung Bok Lee, Jong Hwan Bae, Jong Seung Kim, Yung Choon Yoo, Beom Soo Kim, Sang Tae Kwak, Yeong Shik Kim

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12 Citations (Scopus)

Abstract

Curdlan is a natural β-1,3-glucan produced by Agrobacterium biovar 1. In this study, the anticoagulant activity of sulfoalkyl derivatives of curdlan was investigated by carrying out activated partial thromboplastin time (APTT) assay and compared with that of o-sulfonated curdlan. Approximately 100-fold higher concentration of o-sulfonated curdlan than heparin was required to obtain the same level of the clotting time. Anticoagulant activity of curdlan derivatives was dependent on the degree of sulfation in prolonging the clotting time. However, the chain length of the substituent did not play a role in prolonging the clotting time. The curdlan derivatives enhanced thrombin inhibition by mediating through antithrombin III. The inhibition of thrombin by o-sulfonated curdlan was found to be approximately 10-fold weaker than that by heparin.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalArchives of pharmacal research
Volume24
Issue number2
DOIs
Publication statusPublished - 2001 Jan 1

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Keywords

  • Activated partial thromboplastin time
  • Anticoagulant activity
  • Curdlan
  • Sulfoalkyl derivatives

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Lee, K. B., Bae, J. H., Kim, J. S., Yoo, Y. C., Kim, B. S., Kwak, S. T., & Kim, Y. S. (2001). Anticoagulant Activity of Sulfoalkyl Derivatives of Curdlan. Archives of pharmacal research, 24(2), 109-113. https://doi.org/10.1007/BF02976477