Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis

Hyung Geun Park, Seo Young Yoon, Ji Young Choi, Geum Seon Lee, Jong Hyun Choi, Chan Young Shin, Kun Ho Son, Yong Soo Lee, Won Ki Kim, Jong Hoon Ryu, Kwang Ho Ko, Jae Hoon Cheong

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Abstract

In previous studies, we identified sedative effects of Scutellaria baicalensis extracts and found that these extracts or their constituents may also have anticonvulsive effects. Wogonin is a natural product isolated from S. baicalensis, which possesses central nervous system effects such as anxiolytic and neuroprotective activities. In this study, we investigated the effects of wogonin on convulsion related behaviors, such as myorelaxation, motor coordination, and anticonvulsant effects of wogonin on chemical induced seizure and electroshock seizure in mice or rats. The effect of wogonin on membrane potential was also observed. Wogonin was intraperitoneally injected into mice or rats 30 min prior to testing. Animals treated with wogonin did not change locomotor activities as well as endurance times on the rota-rod, which indicates that wogonin did not cause a sedative and myorelaxation effect. Wogonin significantly blocked convulsion induced by pentylenetetrazole and electroshock but not convulsion induced by strychnine. Wogonin also significantly reduced the electrogenic response score, but flumazenil treatment reversed this decrease to the level of the control group. The wogonin treatment increased Cl-influx into the intracellular area as dose increased. Flumazenil and bicuculline treatment, however, inhibited the Cl- influx induced by wogonin. These results indicate that the anticonvulsive effects produced by wogonin were mediated by the GABAergic neuron.

Original languageEnglish
Pages (from-to)112-119
Number of pages8
JournalEuropean Journal of Pharmacology
Volume574
Issue number2-3
DOIs
Publication statusPublished - 2007 Nov 28

Keywords

  • (Scutellaria baicalensis)
  • GABA
  • Seizure
  • Wogonin

ASJC Scopus subject areas

  • Pharmacology

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    Park, H. G., Yoon, S. Y., Choi, J. Y., Lee, G. S., Choi, J. H., Shin, C. Y., Son, K. H., Lee, Y. S., Kim, W. K., Ryu, J. H., Ko, K. H., & Cheong, J. H. (2007). Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. European Journal of Pharmacology, 574(2-3), 112-119. https://doi.org/10.1016/j.ejphar.2007.07.011