Anticonvulsant effects of new morphinan derivatives

Hyoung Chun Kim, Toshitaka Nabeshima, Wang Kee Jhoo, Kwang Ho Ko, Won-Ki Kim, Eun Joo Shin, Minkyoung Cho, Phil Ho Lee

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.

Original languageEnglish
Pages (from-to)1651-1654
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number13
DOIs
Publication statusPublished - 2001 Jul 9
Externally publishedYes

Fingerprint

Morphinans
Anticonvulsants
Derivatives
Kainic Acid
Rats
Seizures

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Kim, H. C., Nabeshima, T., Jhoo, W. K., Ko, K. H., Kim, W-K., Shin, E. J., ... Lee, P. H. (2001). Anticonvulsant effects of new morphinan derivatives. Bioorganic and Medicinal Chemistry Letters, 11(13), 1651-1654. https://doi.org/10.1016/S0960-894X(01)00262-1

Anticonvulsant effects of new morphinan derivatives. / Kim, Hyoung Chun; Nabeshima, Toshitaka; Jhoo, Wang Kee; Ko, Kwang Ho; Kim, Won-Ki; Shin, Eun Joo; Cho, Minkyoung; Lee, Phil Ho.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 13, 09.07.2001, p. 1651-1654.

Research output: Contribution to journalArticle

Kim, HC, Nabeshima, T, Jhoo, WK, Ko, KH, Kim, W-K, Shin, EJ, Cho, M & Lee, PH 2001, 'Anticonvulsant effects of new morphinan derivatives', Bioorganic and Medicinal Chemistry Letters, vol. 11, no. 13, pp. 1651-1654. https://doi.org/10.1016/S0960-894X(01)00262-1
Kim, Hyoung Chun ; Nabeshima, Toshitaka ; Jhoo, Wang Kee ; Ko, Kwang Ho ; Kim, Won-Ki ; Shin, Eun Joo ; Cho, Minkyoung ; Lee, Phil Ho. / Anticonvulsant effects of new morphinan derivatives. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 13. pp. 1651-1654.
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