Antidepressant prescription pattern in the presence of medical co-morbidity: REAP-AD 2013 Study

S. Grover, A. Avasthi, A. Tripathi, A. J. Tanra, K. Y. Chee, Y. L. He, H. F.K. Chiu, H. Kuga, Min-Soo Lee, M. Y. Chong, P. Udormatn, S. Kanba, S. Y. Yang, T. M. Si, K. Sim, C. H. Tan, W. W. Shen, Y. T. Xiang, N. Sartorius, N. Shinfuku

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To evaluate the prescription pattern of antidepressants in patients with medical co-morbidity from major psychiatric centres in Asia. Methods: The Research on Asian Psychotropic Prescription Pattern for Antidepressants (REAP-AD 2013) collected data from 42 psychiatric centres in 10 Asian countries and regions. Antidepressant prescriptions of 2320 patients with various psychiatric disorders were evaluated. Of these, 370 patients who had specified medical co-morbidities formed the study cohort. Results: Escitalopram (20%) and mirtazapine (20%) were the most commonly prescribed antidepressants in patients with medical co-morbidity followed by sertraline (16%), trazodone (15%), and paroxetine (12%). Overall, more than half (52%; 247/476) of prescriptions comprised selective serotonin reuptake inhibitors. Slightly less than two-thirds (63%; n = 233) of patients received at least 1 selective serotonin reuptake inhibitor. In addition, 79% of patients were prescribed only 1 antidepressant. The mean number of antidepressants used per patient was 1.25 (standard deviation, 0.56). There were subtle differences in the most preferred antidepressant across medical illnesses such as diabetes mellitus, liver dysfunction, acid peptic disease, and cerebrovascular disease. Differences were also seen in prescription patterns across different countries. Conclusion: Although selective serotonin reuptake inhibitors formed the bulk of antidepressant prescriptions in the presence of medical co-morbidity, mirtazapine was also commonly used in the presence of medical co-morbidities. Specified medical morbidities do influence the selection of antidepressants.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalEast Asian Archives of Psychiatry
Volume25
Issue number3
Publication statusPublished - 2015 Sep 1

Fingerprint

Antidepressive Agents
Prescriptions
Morbidity
Serotonin Uptake Inhibitors
Psychiatry
Trazodone
Cerebrovascular Disorders
Sertraline
Paroxetine
Citalopram
Liver Diseases
Digestion
Diabetes Mellitus
Cohort Studies
Acids
Research

Keywords

  • Antidepressive agents
  • Asia
  • Comorbidity

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Grover, S., Avasthi, A., Tripathi, A., Tanra, A. J., Chee, K. Y., He, Y. L., ... Shinfuku, N. (2015). Antidepressant prescription pattern in the presence of medical co-morbidity: REAP-AD 2013 Study. East Asian Archives of Psychiatry, 25(3), 99-107.

Antidepressant prescription pattern in the presence of medical co-morbidity : REAP-AD 2013 Study. / Grover, S.; Avasthi, A.; Tripathi, A.; Tanra, A. J.; Chee, K. Y.; He, Y. L.; Chiu, H. F.K.; Kuga, H.; Lee, Min-Soo; Chong, M. Y.; Udormatn, P.; Kanba, S.; Yang, S. Y.; Si, T. M.; Sim, K.; Tan, C. H.; Shen, W. W.; Xiang, Y. T.; Sartorius, N.; Shinfuku, N.

In: East Asian Archives of Psychiatry, Vol. 25, No. 3, 01.09.2015, p. 99-107.

Research output: Contribution to journalArticle

Grover, S, Avasthi, A, Tripathi, A, Tanra, AJ, Chee, KY, He, YL, Chiu, HFK, Kuga, H, Lee, M-S, Chong, MY, Udormatn, P, Kanba, S, Yang, SY, Si, TM, Sim, K, Tan, CH, Shen, WW, Xiang, YT, Sartorius, N & Shinfuku, N 2015, 'Antidepressant prescription pattern in the presence of medical co-morbidity: REAP-AD 2013 Study', East Asian Archives of Psychiatry, vol. 25, no. 3, pp. 99-107.
Grover S, Avasthi A, Tripathi A, Tanra AJ, Chee KY, He YL et al. Antidepressant prescription pattern in the presence of medical co-morbidity: REAP-AD 2013 Study. East Asian Archives of Psychiatry. 2015 Sep 1;25(3):99-107.
Grover, S. ; Avasthi, A. ; Tripathi, A. ; Tanra, A. J. ; Chee, K. Y. ; He, Y. L. ; Chiu, H. F.K. ; Kuga, H. ; Lee, Min-Soo ; Chong, M. Y. ; Udormatn, P. ; Kanba, S. ; Yang, S. Y. ; Si, T. M. ; Sim, K. ; Tan, C. H. ; Shen, W. W. ; Xiang, Y. T. ; Sartorius, N. ; Shinfuku, N. / Antidepressant prescription pattern in the presence of medical co-morbidity : REAP-AD 2013 Study. In: East Asian Archives of Psychiatry. 2015 ; Vol. 25, No. 3. pp. 99-107.
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abstract = "Objective: To evaluate the prescription pattern of antidepressants in patients with medical co-morbidity from major psychiatric centres in Asia. Methods: The Research on Asian Psychotropic Prescription Pattern for Antidepressants (REAP-AD 2013) collected data from 42 psychiatric centres in 10 Asian countries and regions. Antidepressant prescriptions of 2320 patients with various psychiatric disorders were evaluated. Of these, 370 patients who had specified medical co-morbidities formed the study cohort. Results: Escitalopram (20{\%}) and mirtazapine (20{\%}) were the most commonly prescribed antidepressants in patients with medical co-morbidity followed by sertraline (16{\%}), trazodone (15{\%}), and paroxetine (12{\%}). Overall, more than half (52{\%}; 247/476) of prescriptions comprised selective serotonin reuptake inhibitors. Slightly less than two-thirds (63{\%}; n = 233) of patients received at least 1 selective serotonin reuptake inhibitor. In addition, 79{\%} of patients were prescribed only 1 antidepressant. The mean number of antidepressants used per patient was 1.25 (standard deviation, 0.56). There were subtle differences in the most preferred antidepressant across medical illnesses such as diabetes mellitus, liver dysfunction, acid peptic disease, and cerebrovascular disease. Differences were also seen in prescription patterns across different countries. Conclusion: Although selective serotonin reuptake inhibitors formed the bulk of antidepressant prescriptions in the presence of medical co-morbidity, mirtazapine was also commonly used in the presence of medical co-morbidities. Specified medical morbidities do influence the selection of antidepressants.",
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AU - Chee, K. Y.

AU - He, Y. L.

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AU - Yang, S. Y.

AU - Si, T. M.

AU - Sim, K.

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