Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis

Jong Ho Koh, Kyung Mi Kim, Jin Man Kim, Jae Chul Song, Hyung Joo Suh

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

This study was conducted to investigate the chemical component of the hot water (HW) fraction of mycelia of Cordyceps sinensis and its antifatigue and antistress effect against a stimulus in vivo using rats and mice. The growth of mycelia reached a maximum level of 31.6 g/l after 120 h of incubation. The main chemical composition of the HW fraction of mycelia of C. sinensis was found to be carbohydrate (78.9%) with 5% moisture. The swimming endurance capacity of mice orally administered with the HW fraction (150 and 300 mg/kg/d, respectively) was significantly prolonged from 75 to 90 min with a lessening of fatigue. When the HW fraction (150 mg/kg/d) was given to rats for 8 d including a 48 h stress period, the weight changes of the adrenal gland, spleen, thymus, and thyroid, which is an index of stress, were suppressed. The HW fraction also significantly inhibited the increase in total cholesterol and the decrease in alkaline phosphatase levels as biochemical parameters of immobilization stress in rats.

Original languageEnglish
Pages (from-to)691-694
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume26
Issue number5
Publication statusPublished - 2003 May 1

Keywords

  • Antifatigue
  • Antistress
  • Cordyceps sinensis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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