Antifungal activity of rimocidin and a new rimocidin derivative BU16 produced by Streptomyces mauvecolor BU16 and their effects on pepper anthracnose

B. J. Jeon, J. D. Kim, J. W. Han, Beom Seok Kim

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Aims: The objective of this study was to explore antifungal metabolites targeting fungal cell envelope and to evaluate the control efficacy against anthracnose development in pepper plants. Methods and Results: A natural product library comprising 3000 microbial culture extracts was screened via an adenylate kinase (AK)-based cell lysis assay to detect antifungal metabolites targeting the cell envelope of plant-pathogenic fungi. The culture extract of Streptomyces mauvecolor strain BU16 displayed potent AK-releasing activity. Rimocidin and a new rimocidin derivative, BU16, were identified from the extract as active constituents. BU16 is a tetraene macrolide containing a six-membered hemiketal ring with an ethyl group side chain instead of the propyl group in rimocidin. Rimocidin and BU16 showed broad-spectrum antifungal activity against various plant-pathogenic fungi and demonstrated potent control efficacy against anthracnose development in pepper plants. Conclusions: Antifungal metabolites produced by S. mauvecolor strain BU16 were identified to be rimocidin and BU16. The compounds displayed potent control efficacy against pepper anthracnose. Significance and Impact of the Study: Rimocidin and BU16 would be active ingredients of disease control agents disrupting cell envelope of plant-pathogenic fungi. The structure and antifungal activity of rimocidin derivative BU16 is first described in this study.

Original languageEnglish
Pages (from-to)1219-1228
Number of pages10
JournalJournal of Applied Microbiology
Volume120
Issue number5
DOIs
Publication statusPublished - 2016 May 1

Keywords

  • Colletotrichum coccodes
  • Anthracnose
  • Antifungal agent
  • Microbial metabolites
  • Plant disease control
  • Rimocidin

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Biotechnology

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