Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

Dahyun Hwang, Sung Pil Jo, Jiyun Lee, Jeong Keun Kim, Ki Hyun Kim, Young Hee Lim

Research output: Contribution to journalArticle

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Abstract

The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and acyl coenzyme A cholesterol acyltransferase-2 (ACAT2) were analysed by quantitative real-time reverse-transcription polymerase chain reaction and western blot analysis. ERMO-treated HCD-fed rats had decreased body and liver weights and reduced serum lipid levels, atherogenic index (AI) and coronary artery risk index (CRI). ERMO treatment lowered serum cholesterol levels by increasing the expression of LCAT, CYP7A1 and LDLR and by decreasing HMGCR and ACAT2. Histological analysis of liver and aortic tissues revealed a significant decrease in lipid droplets and foam cell formation in HCD-induced hyperlipidaemic rats treated with ERMO. ERMO is therefore a potentially potent functional food for preventing hyperlipidaemia.

Original languageEnglish
Pages (from-to)353-362
Number of pages10
JournalJournal of Functional Foods
Volume19
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Hypolipidemic Agents
Morus
high fat diet
cholesterol acyltransferase
phosphatidylcholine-choline acyltransferase
Ethanol
Cholesterol
ethanol
low density lipoprotein
Diet
Sterol O-Acyltransferase
rats
extracts
Phosphatidylcholine-Sterol O-Acyltransferase
cholesterol
foam cells
LDL Receptors
cholesterol metabolism
liver
receptors

Keywords

  • Antihyperlipidaemia
  • Atherogenic index
  • Coronary artery risk index
  • Foam cell
  • Oxyresveratrol
  • Ramulus mori

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet. / Hwang, Dahyun; Jo, Sung Pil; Lee, Jiyun; Kim, Jeong Keun; Kim, Ki Hyun; Lim, Young Hee.

In: Journal of Functional Foods, Vol. 19, 01.12.2015, p. 353-362.

Research output: Contribution to journalArticle

Hwang, Dahyun ; Jo, Sung Pil ; Lee, Jiyun ; Kim, Jeong Keun ; Kim, Ki Hyun ; Lim, Young Hee. / Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet. In: Journal of Functional Foods. 2015 ; Vol. 19. pp. 353-362.
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