Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding

Areum Cha, Youngshim Choi, Yoojeong Jin, Mi Kyung Sung, Yun Chang Koo, Kwang Won Lee, Taesun Park

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This study evaluated the antilipogenic and anti-inflammatory effects of Codonopsis lanceolata (C. lanceolata) root extract in mice with alcohol-induced fatty liver and elucidated its underlying molecular mechanisms. Ethanol was introduced into the liquid diet by mixing it with distilled water at 5 (wt/v), providing 36 of the energy, for nine weeks. Among the three different fractions prepared from the C. lanceolata root, the C. lanceolata methanol extract (CME) exhibited the most remarkable attenuation of alcohol-induced fatty liver with respect to various parameters such as hepatic free fatty acid concentration, body weight loss, and hepatic accumulations of triglyceride and cholesterol. The hepatic gene and protein expression levels were analysed via RT-PCR and Western blotting, respectively. CME feeding significantly restored the ethanol-induced downregulation of the adiponectin receptor (adipoR) 1 and of adipoR2, along with their downstream molecules. Furthermore, the study data showed that CME feeding dramatically reversed ethanol-induced hepatic upregulation of toll-like receptor- (TLR-) mediated signaling cascade molecules. These results indicate that the beneficial effects of CME against alcoholic fatty livers of mice appear to be with adenosine- and adiponectin-mediated regulation of hepatic steatosis and TLR-mediated modulation of hepatic proinflammatory responses.

Original languageEnglish
Article number141395
JournalJournal of Biomedicine and Biotechnology
Volume2012
DOIs
Publication statusPublished - 2012 Jan 3

Fingerprint

Codonopsis
Methanol
Anti-Inflammatory Agents
Ethanol
Liver
Tissue
Toll-Like Receptors
Adiponectin Receptors
Alcohols
Fatty Liver
Molecules
Adiponectin
Nutrition
Alcoholic Fatty Liver
Nonesterified Fatty Acids
Adenosine
Triglycerides
Cholesterol
Modulation
Water

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding. / Cha, Areum; Choi, Youngshim; Jin, Yoojeong; Sung, Mi Kyung; Koo, Yun Chang; Lee, Kwang Won; Park, Taesun.

In: Journal of Biomedicine and Biotechnology, Vol. 2012, 141395, 03.01.2012.

Research output: Contribution to journalArticle

Cha, Areum ; Choi, Youngshim ; Jin, Yoojeong ; Sung, Mi Kyung ; Koo, Yun Chang ; Lee, Kwang Won ; Park, Taesun. / Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding. In: Journal of Biomedicine and Biotechnology. 2012 ; Vol. 2012.
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