Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea

Kesinee Chotivanich, Jetsumon Sattabongkot, Kyong Choi Yien, Sun Park Jae, Juntima Sritabal, Seung Lim Chae, Rachanee Udomsangpetch, Nicholas J. White, Ja Lee Won

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC50) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL, pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6, P = 0.004), piperaquine and chloroquine (r = 0.6, P = 0.008), and piperaquine and primaquine IC50 values (r = 0.5, P = 0.01). Compared with P. vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate.

Original languageEnglish
Pages (from-to)902-904
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume80
Issue number6
DOIs
Publication statusPublished - 2009 Jun

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea'. Together they form a unique fingerprint.

  • Cite this

    Chotivanich, K., Sattabongkot, J., Yien, K. C., Jae, S. P., Sritabal, J., Chae, S. L., Udomsangpetch, R., White, N. J., & Won, J. L. (2009). Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea. American Journal of Tropical Medicine and Hygiene, 80(6), 902-904. https://doi.org/10.4269/ajtmh.2009.80.902