Antimicrobial Activities of the Anti-acne Compounds from Natural Sources

Eun Sil Nam, Kim, Narae, Young Hee Lim, Sul Woong Park

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5 Citations (Scopus)

Abstract

The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-log]o-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6. l-logi0-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalKorean Journal of Microbiology and Biotechnology
Volume37
Issue number1
Publication statusPublished - 2009 Mar 1

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Keywords

  • Anti-acne
  • Antimicrobial activity
  • Propionibacterium acnes

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology

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