Antimicrobial activity of native chitosan, degraded chitosan, and O-carboxymethylated chitosan

Kyung W. Kim, R. L. Thomas, Chan Lee, Hyun Jin Park

Research output: Contribution to journalArticle

75 Citations (Scopus)


The antimicrobial activity of native chitosan was compared to that of lipase-degraded chitosan. The effects of O-carboxymethylated (O-CM) substitution on native (molecular weight, 120; degree of deacetylation, 84.71%) and lipase-degraded chitosans were also investigated. The antimicrobial activity of native chitosan was more extensive than that of lipase-degraded chitosan; however, lipase-degraded chitosan was still highly effective and more water-soluble. O-CM chitosan derived from degraded chitosan was more effective than O-CM chitosan derived from native chitosan. O-CM substitution enhanced lipase-degraded chitosan's antimicrobial activity without reducing its solubility.

Original languageEnglish
Pages (from-to)1495-1498
Number of pages4
JournalJournal of Food Protection
Issue number8
Publication statusPublished - 2003 Aug 1


ASJC Scopus subject areas

  • Food Science
  • Applied Microbiology and Biotechnology
  • Biotechnology

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