Antimicrobial prophylaxis using a 2nd generation cephalosporin after laparoscopic colorectal resection: A randomized trial of 1-day vs. 3-day

Han Deok Kwak, Dong Jin Choi, Si Uk Woo, Jin Kim, Jun Won Um, Seon Hahn Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection. Methods: The patients underwent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection. Results: The study included 154 patients (1-day group - 78, vs. 3-day group - 76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456). Conclusion: Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalJournal of the Korean Surgical Society
Volume78
Issue number6
DOIs
Publication statusPublished - 2010 Jun

Keywords

  • Antimicrobial prophylaxis
  • Hospital acquired infection
  • Laparoscopic colorectal surgery
  • Monotherapy
  • Surgical site infection

ASJC Scopus subject areas

  • Surgery

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