Antimicrobial therapy and antimicrobial stewardship in sepsis

Hyeri Seok, Ji Hoon Jeon, Dae Won Park

    Research output: Contribution to journalReview articlepeer-review

    16 Citations (Scopus)


    Since sepsis was first defined, sepsis management has remained challenging. To improve mortality rates for sepsis and septic shock, an accurate diagnosis and prompt administration of appropriate antibiotics are essential. The goals of antimicrobial stewardship are to achieve optimal clinical outcomes and to ensure cost-effectiveness and minimal unintended consequences, such as toxic effects and development of resistant pathogens. A combination of inadequate diagnostic criteria for sepsis and time pressure to provide broad-spectrum antimicrobial therapy remains an obstacle for antimicrobial stewardship. Efforts such as selection of appropriate empirical antibiotics and de-escalation or determination of whether or not to stop antibiotics may help to improve a patient's clinical prognosis as well as the successful implementation of antimicrobial stewardship.

    Original languageEnglish
    Pages (from-to)19-30
    Number of pages12
    JournalInfection and Chemotherapy
    Issue number1
    Publication statusPublished - 2020 Mar 1


    • Antibiotics
    • Antimicrobial stewardship
    • Sepsis
    • Septic shock

    ASJC Scopus subject areas

    • Infectious Diseases
    • Pharmacology (medical)


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