Antioxidant activity of linalool in patients with carpal tunnel syndrome

Geun Hye Seol, Purum Kang, Hui Su Lee, Geun Hee Seol

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS. Methods: This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1 % linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed. Results: DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate. Conclusions: Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.

Original languageEnglish
Article number17
JournalBMC Neurology
Volume16
Issue number1
DOIs
Publication statusPublished - 2016 Feb 2

Fingerprint

Carpal Tunnel Syndrome
Antioxidants
Blood Pressure
Inhalation
Heart Rate
Oxidative Stress
linalool
Peripheral Nervous System Diseases
Volatile Oils
Nitrites
Reperfusion Injury
Double-Blind Method
Oils

Keywords

  • Antioxidative activity
  • Carpal tunnel syndrome
  • Linalool

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Antioxidant activity of linalool in patients with carpal tunnel syndrome. / Seol, Geun Hye; Kang, Purum; Lee, Hui Su; Seol, Geun Hee.

In: BMC Neurology, Vol. 16, No. 1, 17, 02.02.2016.

Research output: Contribution to journalArticle

Seol, Geun Hye ; Kang, Purum ; Lee, Hui Su ; Seol, Geun Hee. / Antioxidant activity of linalool in patients with carpal tunnel syndrome. In: BMC Neurology. 2016 ; Vol. 16, No. 1.
@article{964a066a077a4198bf2f01628f11f53b,
title = "Antioxidant activity of linalool in patients with carpal tunnel syndrome",
abstract = "Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS. Methods: This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1 {\%} linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed. Results: DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate. Conclusions: Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.",
keywords = "Antioxidative activity, Carpal tunnel syndrome, Linalool",
author = "Seol, {Geun Hye} and Purum Kang and Lee, {Hui Su} and Seol, {Geun Hee}",
year = "2016",
month = "2",
day = "2",
doi = "10.1186/s12883-016-0541-3",
language = "English",
volume = "16",
journal = "BMC Neurology",
issn = "1471-2377",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Antioxidant activity of linalool in patients with carpal tunnel syndrome

AU - Seol, Geun Hye

AU - Kang, Purum

AU - Lee, Hui Su

AU - Seol, Geun Hee

PY - 2016/2/2

Y1 - 2016/2/2

N2 - Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS. Methods: This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1 % linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed. Results: DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate. Conclusions: Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.

AB - Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS. Methods: This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1 % linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed. Results: DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate. Conclusions: Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.

KW - Antioxidative activity

KW - Carpal tunnel syndrome

KW - Linalool

UR - http://www.scopus.com/inward/record.url?scp=84956736323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956736323&partnerID=8YFLogxK

U2 - 10.1186/s12883-016-0541-3

DO - 10.1186/s12883-016-0541-3

M3 - Article

C2 - 26831333

AN - SCOPUS:84956736323

VL - 16

JO - BMC Neurology

JF - BMC Neurology

SN - 1471-2377

IS - 1

M1 - 17

ER -