TY - JOUR
T1 - Antioxidant activity of linalool in patients with carpal tunnel syndrome
AU - Seol, Geun Hye
AU - Kang, Purum
AU - Lee, Hui Su
AU - Seol, Geun Hee
N1 - Funding Information:
This work was supported by a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No.2012R1A2A2A02007145).
Publisher Copyright:
© 2016 Seol et al.
PY - 2016/2/2
Y1 - 2016/2/2
N2 - Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS. Methods: This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1 % linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed. Results: DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate. Conclusions: Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.
AB - Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS. Methods: This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1 % linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed. Results: DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate. Conclusions: Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.
KW - Antioxidative activity
KW - Carpal tunnel syndrome
KW - Linalool
UR - http://www.scopus.com/inward/record.url?scp=84956736323&partnerID=8YFLogxK
U2 - 10.1186/s12883-016-0541-3
DO - 10.1186/s12883-016-0541-3
M3 - Article
C2 - 26831333
AN - SCOPUS:84956736323
VL - 16
JO - BMC Neurology
JF - BMC Neurology
SN - 1471-2377
IS - 1
M1 - 17
ER -