Antioxidant activity of linalool in patients with carpal tunnel syndrome

Geun Hye Seol, Purum Kang, Hui Su Lee, Geun Hee Seol

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS. Methods: This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1 % linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed. Results: DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate. Conclusions: Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.

Original languageEnglish
Article number17
JournalBMC Neurology
Volume16
Issue number1
DOIs
Publication statusPublished - 2016 Feb 2

Keywords

  • Antioxidative activity
  • Carpal tunnel syndrome
  • Linalool

ASJC Scopus subject areas

  • Clinical Neurology

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