Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A. DC

Ji Young Lee, Jae Wook Yoon, Cheong Tae Kim, Seung Taik Lim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Antioxidant compounds were isolated from the petroleum ether extracts of Platycodon grandiflorum root, i.e. (coniferyl alcohol esters with palmitic acid 1 and oleic acid 2). Platycodon grandiflorum A. DC (Campanulaceae) is used as a traditional oriental medicine and also as a food in Korea. Here we investigated its antioxidant activity, and isolated and identified its active compounds. Petroleum ether extracts from the whole root of P. grandiflorum were fractionated by silica gel column chromatography using a solvent gradient (petroleum ether:diethyl ether, v/v; 9:1-5:5). The 8:2 fraction showed a higher radical scavenging activity than the other fractions, and active compounds were purified from this fraction by reversed-phased HPLC. Two active compounds were identified as coniferyl alcohol esters of palmitic and oleic acids by FAB-MS, UV, IR and NMR spectroscopy. The antioxidant activities of these two compounds, which were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide and nitric oxide radical scavenging capacity, were found to be as high as those of BHT or BHA.

Original languageEnglish
Pages (from-to)3033-3039
Number of pages7
JournalPhytochemistry
Volume65
Issue number22
DOIs
Publication statusPublished - 2004 Nov

Keywords

  • Antioxidant
  • Campanulaceae
  • Coniferyl alcohol
  • Phenylpropanoid
  • Platycodon grandiflorum
  • Radical scavenging

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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