Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat

Yong Soo Kwon, Dae Hun Park, Eun Joo Shin, Myung Sang Kwon, Kwang Ho Ko, Won Ki Kim, Jin Hyeong Jhoo, Wang Kee Jhoo, Myung Bok Wie, Bae Dong Jung, Hyoung Chun Kim

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


We examined the effects of the antioxidant propolis on seizures induced by kainic acid (KA). Sprague-Dawley rats received propolis (75 and 150 mg/kg, p.o.) five times at 12 h intervals. KA (10 mg/kg, i.p.) was injected 1 h after the last propolis treatment. Pretreatment with propolis significantly attenuated KA-induced seizures and KA-induced increases in hippocampal AP-1 DNA binding activity in a dose-dependent manner. KA induced increases in the levels of malondialdehyde and protein carbonyl, and a decrease in the ratio of GSH/GSSG. These oxidative stresses and neuronal degenerations were significantly attenuated by pretreatment with propolis. The neuroprotective effects of propolis appeared to be counteracted by adenosine receptor antagonists [A 1 antagonist, 8-cyclopentyl-1,3-dimethylxanthine (25 or 50 μg/kg) ; A2A antagonist, 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine (0.5 or 1 mg/kg); and A2B antagonist, alloxazine (1.5 or 3.0 mg/kg)]. However, this counteraction was most pronounced in the presence of the A 1 antagonist. Our results suggest that the protective effect of propolis against KA-induced neurotoxic oxidative damage is, at least in part, via adenosine A1 receptor modulation.

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 2004 Jan 30
Externally publishedYes


  • AP-1 DNA binding activity
  • Adenosine receptors
  • Hippocampus
  • Kainate
  • Oxidative stress
  • Propolis
  • Ratio of GSH/GSSG

ASJC Scopus subject areas

  • Neuroscience(all)


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