Antioxidative oligostilbenes from Caragana sinica

Qinghao Jin, Xiang Hua Han, Seong Su Hong, Chul Lee, Sanggil Choe, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

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22 Citations (Scopus)

Abstract

Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the roots of Caragana sinica. The structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1D, 2D NMR and HRESI-MS. These compounds were assessed for antioxidant activities. Caragasinin A (5), caraphenol B (9), and caragasinin B (10) showed moderate DPPH scavenging activity and lipid peroxidation inhibitory activities with IC 50 values ranging from 34.7 ± 1.0 to 89.1 ± 2.3 μM.

Original languageEnglish
Pages (from-to)973-976
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number2
DOIs
Publication statusPublished - 2012 Jan 15

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Keywords

  • Antioxidant activity
  • Caragana sinica
  • Fabaceae
  • Oligostilbenes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Jin, Q., Han, X. H., Hong, S. S., Lee, C., Choe, S., Lee, D., Kim, Y., Hong, J. T., Lee, M. K., & Hwang, B. Y. (2012). Antioxidative oligostilbenes from Caragana sinica. Bioorganic and Medicinal Chemistry Letters, 22(2), 973-976. https://doi.org/10.1016/j.bmcl.2011.12.012