Antioxidative oligostilbenes from Caragana sinica

Qinghao Jin, Xiang Hua Han, Seong Su Hong, Chul Lee, Sanggil Choe, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the roots of Caragana sinica. The structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1D, 2D NMR and HRESI-MS. These compounds were assessed for antioxidant activities. Caragasinin A (5), caraphenol B (9), and caragasinin B (10) showed moderate DPPH scavenging activity and lipid peroxidation inhibitory activities with IC 50 values ranging from 34.7 ± 1.0 to 89.1 ± 2.3 μM.

Original languageEnglish
Pages (from-to)973-976
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number2
DOIs
Publication statusPublished - 2012 Jan 15

Fingerprint

Caragana
Spectroscopic analysis
Scavenging
Lipid Peroxidation
Antioxidants
Nuclear magnetic resonance
Lipids
caraphenol B

Keywords

  • Antioxidant activity
  • Caragana sinica
  • Fabaceae
  • Oligostilbenes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Jin, Q., Han, X. H., Hong, S. S., Lee, C., Choe, S., Lee, D., ... Hwang, B. Y. (2012). Antioxidative oligostilbenes from Caragana sinica. Bioorganic and Medicinal Chemistry Letters, 22(2), 973-976. https://doi.org/10.1016/j.bmcl.2011.12.012

Antioxidative oligostilbenes from Caragana sinica. / Jin, Qinghao; Han, Xiang Hua; Hong, Seong Su; Lee, Chul; Choe, Sanggil; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 2, 15.01.2012, p. 973-976.

Research output: Contribution to journalArticle

Jin, Q, Han, XH, Hong, SS, Lee, C, Choe, S, Lee, D, Kim, Y, Hong, JT, Lee, MK & Hwang, BY 2012, 'Antioxidative oligostilbenes from Caragana sinica', Bioorganic and Medicinal Chemistry Letters, vol. 22, no. 2, pp. 973-976. https://doi.org/10.1016/j.bmcl.2011.12.012
Jin, Qinghao ; Han, Xiang Hua ; Hong, Seong Su ; Lee, Chul ; Choe, Sanggil ; Lee, Dongho ; Kim, Youngsoo ; Hong, Jin Tae ; Lee, Mi Kyeong ; Hwang, Bang Yeon. / Antioxidative oligostilbenes from Caragana sinica. In: Bioorganic and Medicinal Chemistry Letters. 2012 ; Vol. 22, No. 2. pp. 973-976.
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