Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors

Keejung Kang, Yongju Park, Jeong Hwang Hye, Ho Kim Seong, Gu Lee Jeong, Hyeon Cheol Shin

    Research output: Contribution to journalArticlepeer-review

    116 Citations (Scopus)

    Abstract

    Several polyphenolic compounds and complex mixtures were isolated from brown algae species. The 1,1-diphenyl-2-picryhydarzyl (DPPH) radical scavenging activity and ferric reducing antioxidant power (FRAP) of these compounds were evaluated to determine their physiological usefulness as antioxidants for vascular protection. The antioxidative protection of low-density lipoprotein (LDL) was also evaluated and compared with that of catechin, because the generation of oxidized LDL is one of the most active and specific risk factors contributing to atherogenesis. Oral administration to rats of a commercially available sample (VNPTM) containing 30% of these polyphenolic compounds and 70% dietary fiber revealed that the serum reducing capacity measured in terms of FRAP value was significantly elevated 30 min after the treatment, but declined rather quickly thereafter, indicating the good oral absorption of the compounds and their fast binding to the lumenal surface of the blood vessels. An eight-week, human, clinical trial (n=31) of VNPTM showed significant improvement in erectile function measured by IIEF (international index of erectile function) score. These results collectively demonstrated the usefulness of these polyphenolic compounds as fundamental chemopreventive agents against vascular risk factors originating from oxidative stress.

    Original languageEnglish
    Pages (from-to)286-293
    Number of pages8
    JournalArchives of pharmacal research
    Volume26
    Issue number4
    DOIs
    Publication statusPublished - 2003 Apr 30

    Keywords

    • Antioxidative
    • Brown algae polyphenolics
    • Endothelial
    • Erectile function
    • Oxidized LDL
    • Vascular protection

    ASJC Scopus subject areas

    • Molecular Medicine
    • Drug Discovery
    • Organic Chemistry

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