Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Nahyun Kim, Kyu Won Cho, Seong Su Hong, Bang Yeon Hwang, Taehoon Chun, Dongho Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.

Original languageEnglish
Pages (from-to)621-625
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number3
DOIs
Publication statusPublished - 2015 Feb 1

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Dictamnus
T-cells
T-Lymphocytes
Rutaceae
Immunosuppressive Agents
Fractionation
Inhibitory Concentration 50
Assays
Nuclear magnetic resonance
Experiments

Keywords

  • Antiproliferative effect
  • Dictamnus dasycarpus
  • Glabretal-type triterpenoid
  • Rutaceae

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus. / Kim, Nahyun; Cho, Kyu Won; Hong, Seong Su; Hwang, Bang Yeon; Chun, Taehoon; Lee, Dongho.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 3, 01.02.2015, p. 621-625.

Research output: Contribution to journalArticle

Kim, Nahyun ; Cho, Kyu Won ; Hong, Seong Su ; Hwang, Bang Yeon ; Chun, Taehoon ; Lee, Dongho. / Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus. In: Bioorganic and Medicinal Chemistry Letters. 2015 ; Vol. 25, No. 3. pp. 621-625.
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