Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Nahyun Kim; Kyu Won Cho; Seong Su Hong; Bang Yeon Hwang; Taehoon Chun; Dongho Lee

doi:10.1016/j.bmcl.2014.12.007

Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Nahyun Kim, Kyu Won Cho, Seong Su Hong, Bang Yeon Hwang, Taehoon Chun, Dongho Lee

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC₅₀ of 1.5 μM.

Original language	English
Pages (from-to)	621-625
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2014.12.007
Publication status	Published - 2015 Feb 1

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Keywords

Antiproliferative effect
Dictamnus dasycarpus
Glabretal-type triterpenoid
Rutaceae

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Molecular Biology
Molecular Medicine
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Cite this

Kim, N., Cho, K. W., Hong, S. S., Hwang, B. Y., Chun, T., & Lee, D. (2015). Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus. Bioorganic and Medicinal Chemistry Letters, 25(3), 621-625. https://doi.org/10.1016/j.bmcl.2014.12.007

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10.1016/j.bmcl.2014.12.007