Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Nahyun Kim; Kyu Won Cho; Seong Su Hong; Bang Yeon Hwang; Taehoon Chun; Dongho Lee

doi:10.1016/j.bmcl.2014.12.007

Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Nahyun Kim, Kyu Won Cho, Seong Su Hong, Bang Yeon Hwang, Taehoon Chun, Dongho Lee

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC₅₀ of 1.5 μM.

Original language	English
Pages (from-to)	621-625
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2014.12.007
Publication status	Published - 2015 Feb 1

Keywords

Antiproliferative effect
Dictamnus dasycarpus
Glabretal-type triterpenoid
Rutaceae

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus",

abstract = "Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.",

keywords = "Antiproliferative effect, Dictamnus dasycarpus, Glabretal-type triterpenoid, Rutaceae",

author = "Nahyun Kim and Cho, {Kyu Won} and Hong, {Seong Su} and Hwang, {Bang Yeon} and Taehoon Chun and Dongho Lee",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2013R1A6A3A01064888 ) and a Korea University Grant. Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.bmcl.2014.12.007",

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AU - Cho, Kyu Won

AU - Hong, Seong Su

AU - Hwang, Bang Yeon

AU - Chun, Taehoon

AU - Lee, Dongho

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2013R1A6A3A01064888 ) and a Korea University Grant. Publisher Copyright: © 2014 Elsevier Ltd. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

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Y1 - 2015/2/1

N2 - Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.

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Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Abstract

Keywords

ASJC Scopus subject areas

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