TY - JOUR
T1 - Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus
AU - Kim, Nahyun
AU - Cho, Kyu Won
AU - Hong, Seong Su
AU - Hwang, Bang Yeon
AU - Chun, Taehoon
AU - Lee, Dongho
N1 - Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2013R1A6A3A01064888 ) and a Korea University Grant.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.
AB - Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.
KW - Antiproliferative effect
KW - Dictamnus dasycarpus
KW - Glabretal-type triterpenoid
KW - Rutaceae
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U2 - 10.1016/j.bmcl.2014.12.007
DO - 10.1016/j.bmcl.2014.12.007
M3 - Article
C2 - 25537268
AN - SCOPUS:84920727361
VL - 25
SP - 621
EP - 625
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 3
ER -