Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Nahyun Kim; Kyu Won Cho; Seong Su Hong; Bang Yeon Hwang; Taehoon Chun; Dongho Lee

doi:10.1016/j.bmcl.2014.12.007

Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Nahyun Kim, Kyu Won Cho, Seong Su Hong, Bang Yeon Hwang, Taehoon Chun, Dongho Lee

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC₅₀ of 1.5 μM.

Original language	English
Pages (from-to)	621-625
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2014.12.007
Publication status	Published - 2015 Feb 1

Keywords

Antiproliferative effect
Dictamnus dasycarpus
Glabretal-type triterpenoid
Rutaceae

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2014.12.007

Cite this

@article{d26cf7253ec347c3a48d43e8e927f616,

title = "Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus",

abstract = "Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.",

keywords = "Antiproliferative effect, Dictamnus dasycarpus, Glabretal-type triterpenoid, Rutaceae",

author = "Nahyun Kim and Cho, {Kyu Won} and Hong, {Seong Su} and Hwang, {Bang Yeon} and Taehoon Chun and Dongho Lee",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2013R1A6A3A01064888 ) and a Korea University Grant. Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.bmcl.2014.12.007",

language = "English",

volume = "25",

pages = "621--625",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

AU - Kim, Nahyun

AU - Cho, Kyu Won

AU - Hong, Seong Su

AU - Hwang, Bang Yeon

AU - Chun, Taehoon

AU - Lee, Dongho

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2013R1A6A3A01064888 ) and a Korea University Grant. Publisher Copyright: © 2014 Elsevier Ltd. All rights reserved.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.

AB - Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.

KW - Antiproliferative effect

KW - Dictamnus dasycarpus

KW - Glabretal-type triterpenoid

KW - Rutaceae

UR - http://www.scopus.com/inward/record.url?scp=84920727361&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2014.12.007

DO - 10.1016/j.bmcl.2014.12.007

M3 - Article

C2 - 25537268

AN - SCOPUS:84920727361

VL - 25

SP - 621

EP - 625

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 3

ER -

Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this