Abstract
Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 621-625 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Feb 1 |
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Keywords
- Antiproliferative effect
- Dictamnus dasycarpus
- Glabretal-type triterpenoid
- Rutaceae
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Molecular Biology
- Molecular Medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus. / Kim, Nahyun; Cho, Kyu Won; Hong, Seong Su; Hwang, Bang Yeon; Chun, Taehoon; Lee, Dongho.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 3, 01.02.2015, p. 621-625.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus
AU - Kim, Nahyun
AU - Cho, Kyu Won
AU - Hong, Seong Su
AU - Hwang, Bang Yeon
AU - Chun, Taehoon
AU - Lee, Dongho
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.
AB - Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.
KW - Antiproliferative effect
KW - Dictamnus dasycarpus
KW - Glabretal-type triterpenoid
KW - Rutaceae
UR - http://www.scopus.com/inward/record.url?scp=84920727361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920727361&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2014.12.007
DO - 10.1016/j.bmcl.2014.12.007
M3 - Article
C2 - 25537268
AN - SCOPUS:84920727361
VL - 25
SP - 621
EP - 625
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 3
ER -