Abstract
Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 621-625 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Feb 1 |
Keywords
- Antiproliferative effect
- Dictamnus dasycarpus
- Glabretal-type triterpenoid
- Rutaceae
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Molecular Biology
- Molecular Medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
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Cite this
Kim, N., Cho, K. W., Hong, S. S., Hwang, B. Y., Chun, T., & Lee, D. (2015). Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus. Bioorganic and Medicinal Chemistry Letters, 25(3), 621-625. https://doi.org/10.1016/j.bmcl.2014.12.007