Antiproliferative role of dopamine: Loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia

Adolfo Saiardi, Yuri Bozzi, Ja Hyun Baik, Emiliana Borrelli

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The function of dopamine (DA) in the nervous system is paralleled by its neuroendocrine control of pituitary gland functions. Here, we document the neuroendocrine function of dopamine by studying the pituitary gland of mice lacking DA D2 receptors (D2R). These mice present a striking, progressive increase in lactotroph number, which ultimately leads to tumors in aged animals. Females develop tumors much earlier than males. An estrogen-mediated lactotroph proliferation cannot account for this sexual dimorphism, since D2R-null females are hypoestrogenic and, thus, have estrogen levels similar to males. In contrast, prolactin levels are six times higher in females than in males. We show that active prolactin receptors are present in the pituitary and their expression increases in concomitance with tumor expansion. These results point to prolactin as an autocrine proliferative factor in the pituitary gland. Additionally, they demonstrate an antiproliferatire function for DA regulated through D2 receptor activation.

Original languageEnglish
Pages (from-to)115-126
Number of pages12
JournalNeuron
Volume19
Issue number1
DOIs
Publication statusPublished - 1997 Jul

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Antiproliferative role of dopamine: Loss of D<sub>2</sub> receptors causes hormonal dysfunction and pituitary hyperplasia'. Together they form a unique fingerprint.

  • Cite this