Antitumor activity of Lactobacillus plantarum cytoplasm on teratocarcinoma-bearing mice

Ji Yeon Kim, Hee Jong Woo, Kyoung Heon Kim, Eung Ryool Kim, Hoo K. Jung, Ho N. Juhn, Hyong Joo Lee

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Abstract

Potential antitumor activity of Lactobacillus plantarum cytoplasm was examined using F9 teratocarcinoma-bearing BALB/c mice. The cytoplasmic fraction of L. plantarum was separated by sonication followed by ultracentrifugation. The fraction at a dose of 100 or 200 mg/kg/day was orally administered for 7 consecutive days before or after tumor inoculation to 16 mice. As a control, heat-killed whole cell was used at a dose of 100 mg/kg/day. Upon oral administrations of both the cytoplasm and heat-killed whole cell, when performed after and before tumor inoculation, the survival of F9-bearing mice prolonged more effectively. Administration of the cytoplasm after tumor inoculation extended the average survival days by 30 and 40% at daily dosages of 100 and 200 mg/kg/day, respectively. This result suggests that the cytoplasmic fraction of L. plantarum has strong antitumor activity against mouse F9 teratocarcinoma in vivo.

Original languageEnglish
Pages (from-to)998-1001
Number of pages4
JournalJournal of Microbiology and Biotechnology
Volume12
Issue number6
Publication statusPublished - 2002 Dec 1
Externally publishedYes

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Keywords

  • Antitumor
  • Cytoplasm
  • Lactobacillus plantarum
  • Teratocarcinoma

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Kim, J. Y., Woo, H. J., Kim, K. H., Kim, E. R., Jung, H. K., Juhn, H. N., & Lee, H. J. (2002). Antitumor activity of Lactobacillus plantarum cytoplasm on teratocarcinoma-bearing mice. Journal of Microbiology and Biotechnology, 12(6), 998-1001.