Antitumor activity of the aqueous-alcoholic extracts from unripe cotton ball of Gossypium indicum

Jung Jin Choi, Keum Na Yoon, Seung Ki Lee, Yong Hee Lee, Jeong Hill Park, Wang Yu Kim, Joon Kyum Kim, Won Ki Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study investigated the antitumor activity of the aqueous-alcoholic extracts from unripe cotton balls of Gossypium indicum. An Exposure of murine B16 melanoma and L1210 lymphoma cells to the extracts resulted in their severe deaths in time- and concentration-dependent manners. Of the extracts, hydrophilic fractions were most efficacious for the antitumor activity and found to contain certain amounts of catechin and its derivatives. The hydrophilic extract fraction C36B2-8 had approximately 10 times more cytotoxic effects on B12 and L1210 cells than on isolated murine thymocytes. High concentrations (>150 μg/m\) of C 36B3-8 mainly induced necrotic cell death. At low concentrations (<100 μg/ml), however, C 36B3-8 induced not only necrosis but also apoptosis of the two tumor cell lines, which was proved by the TUNEL staining and DNA fragmentation techniques. The data indicate that certain ingredients of the cotton ball extract of G. indicum have an antitumor activity.

Original languageEnglish
Pages (from-to)266-272
Number of pages7
JournalArchives of pharmacal research
Volume21
Issue number3
DOIs
Publication statusPublished - 1998 Jun
Externally publishedYes

Keywords

  • Anticancer activity
  • Apoptosis
  • B16 melanoma
  • Cotton ball
  • Gossypium indicum
  • L1210 leukemia
  • Necrosis
  • Thymocytes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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