Antitumor effects of IL-6 on murine liver tumor cells in vivo

Hyung Sik Kang, Dae Ho Cho, Sung Sook Kim, Kwang Ho Pyun, Inpyo Choi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

IL-6 is a pleiotropic cytokine that is capable of modulating the diverse functions of hepatocytes such as acute phase responses and inflammation in the liver. To learn its antitumor effects in vivo, the cDNA of IL-6 was transfected into murine liver cells, TIB cells. IL-6-transfected TIB cells (TIB73-IL-6 or TIB75-IL-6) produced much higher levels of IL-6 compared with vector-transfected TIB cells (TIB73-vec or TIB75-vec). To investigate the effects of IL-6 on TIB tumor growth in vivo, IL-6-transfected TIB cells or vector-transfected TIB cells were injected subcutaneously into syngeneic mice. Vector-transfected TIB cells grew rapidly 3 weeks after injection, but IL-6-transfected TIB cells did not grow at all for up to 6 weeks. Pathologically, IL-6-transfected TIB cells demonstrated a severe necrosis and apoptotic pattern. Taken together, these results indicate that IL-6 functions as a growth inhibiting factor in vivo, and another biological role of IL-6 in the liver is suggested.

Original languageEnglish
Pages (from-to)142-144
Number of pages3
JournalJournal of Biomedical Science
Volume6
Issue number2
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Antitumor effects
  • Host immunity
  • Interleukin-6
  • Liver tumor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

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