Antiviral activity of angelicin against gammaherpesviruses

Hye Jeong Cho, Seon Gyeong Jeong, Ji Eun Park, Jin Ah Han, Hye Ri Kang, Dongho Lee, Moon Jung Song

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Human gammaherpesviruses including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are important pathogens as they persist in the host and cause various malignancies. However, few antiviral drugs are available to efficiently control gammaherpesvirus replication. Here we identified the antiviral activity of angelicin against murine gammaherpesvirus 68 (MHV-68), genetically and biologically related to human gammaherpesviruses. Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, efficiently inhibited lytic replication of MHV-68 in a dose-dependent manner following the virus entry. The IC50 of angelicin antiviral activity was estimated to be 28.95 μM, while the CC50 of angelicin was higher than 2600 μM. Furthermore, incubation with angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells. Taken together, these results suggest that MHV-68 can be a useful tool to screen novel antiviral agents against human gammaherepsviruses and that angelicin may provide a lead structure for the development of antiviral drug against gammaherpesviruses.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalAntiviral Research
Volume100
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Angelicin
  • Antiviral activity
  • EBV
  • Furocoumarins
  • KSHV
  • MHV-68

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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