Abstract
Aim: To compare the antiviral efficacy of adefovir (ADV) in lamivudine (LMV)-resistant patients with LMV treatment in nucleoside-naïve patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV. Methods: Forty-four patients with chronic hepatitis B (CHB) were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following: reduction in serum HBV DNA from baseline, HBV DNA negative conversion (defined as HBV DNA being undectable by the hybridization assay), and HBV DNA response (either HBV DNA level 105 copies/mL or a 2 log10 reduction from baseline HBV DNA level). Results: After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment (P = 0.021). HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively (P = 0.001). Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively (P = 0.026). The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV. Conclusion: The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naïve patients during the early course of treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 4072-4079 |
| Number of pages | 8 |
| Journal | World Journal of Gastroenterology |
| Volume | 13 |
| Issue number | 30 |
| Publication status | Published - 2007 Aug 14 |
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Keywords
- Adefovir
- Chronic hepatitis B
- Lamivudine
- Treatment efficacy
ASJC Scopus subject areas
- Gastroenterology
Cite this
Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance. / Seo, Yeon Seok; Kim, Ji Hoon; Yeon, Jong Eun; Park, Jong Jae; Kim, Jae Seon; Byun, Kwan Soo; Bak, Young-Tae; Lee, Chang Hong.
In: World Journal of Gastroenterology, Vol. 13, No. 30, 14.08.2007, p. 4072-4079.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance
AU - Seo, Yeon Seok
AU - Kim, Ji Hoon
AU - Yeon, Jong Eun
AU - Park, Jong Jae
AU - Kim, Jae Seon
AU - Byun, Kwan Soo
AU - Bak, Young-Tae
AU - Lee, Chang Hong
PY - 2007/8/14
Y1 - 2007/8/14
N2 - Aim: To compare the antiviral efficacy of adefovir (ADV) in lamivudine (LMV)-resistant patients with LMV treatment in nucleoside-naïve patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV. Methods: Forty-four patients with chronic hepatitis B (CHB) were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following: reduction in serum HBV DNA from baseline, HBV DNA negative conversion (defined as HBV DNA being undectable by the hybridization assay), and HBV DNA response (either HBV DNA level 105 copies/mL or a 2 log10 reduction from baseline HBV DNA level). Results: After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment (P = 0.021). HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively (P = 0.001). Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively (P = 0.026). The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV. Conclusion: The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naïve patients during the early course of treatment.
AB - Aim: To compare the antiviral efficacy of adefovir (ADV) in lamivudine (LMV)-resistant patients with LMV treatment in nucleoside-naïve patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV. Methods: Forty-four patients with chronic hepatitis B (CHB) were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following: reduction in serum HBV DNA from baseline, HBV DNA negative conversion (defined as HBV DNA being undectable by the hybridization assay), and HBV DNA response (either HBV DNA level 105 copies/mL or a 2 log10 reduction from baseline HBV DNA level). Results: After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment (P = 0.021). HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively (P = 0.001). Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively (P = 0.026). The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV. Conclusion: The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naïve patients during the early course of treatment.
KW - Adefovir
KW - Chronic hepatitis B
KW - Lamivudine
KW - Treatment efficacy
UR - http://www.scopus.com/inward/record.url?scp=34548240700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548240700&partnerID=8YFLogxK
M3 - Article
C2 - 17696224
AN - SCOPUS:34548240700
VL - 13
SP - 4072
EP - 4079
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 30
ER -