Anxiety and depression propensities in patients with acute toxic liver injury

Jeong Ill Suh, Jeong Kyu Sakong, Kwan Lee, Yong Kook Lee, Jeong Bae Park, Dong Joon Kim, Yeon Seok Seo, Jae Dong Lee, Soon Young Ko, Byung Seok Lee, Seok Hyun Kim, Byung Seok Kim, Young Seok Kim, Heon Ju Lee, In Hee Kim, Joo Hyun Sohn, Tae Yeob Kim, Byung Min Ahn

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

AIM: To investigate anxiety and depression propensities in patients with toxic liver injury. METHODS: The subjects were divided into three groups: a healthy control group (Group 1, n = 125), an acute non-toxic liver injury group (Group 2, n = 124), and a group with acute toxic liver injury group caused by noncommercial herbal preparations (Group 3, n = 126). These three groups were compared and evaluated through questionnaire surveys and using the Hospital Anxiety-Depression Scale (HADS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and the hypochondriasis scale. RESULTS: The HADS anxiety subscale was 4.9 ± 2.7, 5.0 ± 3.0 and 5.6 ± 3.4, in Groups 1, 2, and 3, respectively. The HADS depression subscale in Group 3 showed the most significant score (5.2 ± 3.2, 6.4 ± 3.4 and 7.2 ± 3.4 in Groups 1, 2, and 3, respectively) (P < 0.01 vs Group 1, P < 0.05 vs Group 2). The BAI and BDI in Group 3 showed the most significant score (7.0 ± 6.3 and 6.9 ± 6.9, 9.5 ± 8.6 and 8.8 ± 7.3, 10.7 ± 7.2 and 11.6 ± 8.5 in Groups 1, 2, and 3, respectively) (BAI: P < 0.01 vs Group 1, P < 0.05 vs Group 2) (BDI: P < 0.01 vs Group 1 and 2). Group 3 showed a significantly higher hypochondriasis score (8.2 ± 6.0, 11.6 ± 7.5 and 13.1 ± 6.5 in Groups 1, 2, and 3, respectively) (P < 0.01 vs Group 1, P < 0.05 vs Group 2). CONCLUSION: Psychological factors that present vulnerability to the temptation to use alternative medicines, such as herbs and plant preparations, are important for understanding toxic liver injury.

Original languageEnglish
Pages (from-to)9069-9076
Number of pages8
JournalWorld journal of gastroenterology
Volume19
Issue number47
DOIs
Publication statusPublished - 2013 Dec 21

Keywords

  • Anxiety
  • Depression
  • Herb
  • Liver injury
  • Toxic

ASJC Scopus subject areas

  • Gastroenterology

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    Suh, J. I., Sakong, J. K., Lee, K., Lee, Y. K., Park, J. B., Kim, D. J., Seo, Y. S., Lee, J. D., Ko, S. Y., Lee, B. S., Kim, S. H., Kim, B. S., Kim, Y. S., Lee, H. J., Kim, I. H., Sohn, J. H., Kim, T. Y., & Ahn, B. M. (2013). Anxiety and depression propensities in patients with acute toxic liver injury. World journal of gastroenterology, 19(47), 9069-9076. https://doi.org/10.3748/wjg.v19.i47.9069