Apoptosis in thymic epithelial tumors

Sung Hye Park, Han Kyeom Kim, Hanseong Kim, Jae Y. Ro

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    We studied Fas/FasL, Bcl-2, and M30 CytoDeath in five cases of normal thymus and 41 cases of thymic epithelial tumors (TETs). In normal thymus, Fas was expressed in all epithelial cells, but not in thymic lymphocytes; FasL was weakly expressed only in medullary epithelium and Hassal's corpuscles. In TETs, Fas was expressed in all epithelial cells and lymphocytes, while FasL was differently expressed in epithelial cells of different subtypes of TETs, i.e., type A (2/2), AB (12/12), B1 (0/9), B1/B2 (0/3), B2 (0/1), B2/B3 (1/3), B3 (6/10) and C (1/1), but not in lymphocytes. Bcl2 protein was strongly expressed in medullary-derived lymphocytes of normal thymus and TETs, and weakly expressed only in medullary (spindle) epithelium of TETs. On M30 CytoDeath immunostaining, apoptotic indices were very low in all TETs (0-1.2). In conclusion, since FasL was expressed on the epithelial cells of lymphocyte-depleted (LD) areas of type B2/B3 and/or LD subtypes (type A, AB, B3, C), FasL expression could be relevant for the intracytoplasmic processes of T-cell selection and the regulation of the lymphoid cells inside the tumor, at least partly. However, tumorigenesis of TETs is not necessarily induced by abrogation of apoptosis.

    Original languageEnglish
    Pages (from-to)461-467
    Number of pages7
    JournalPathology Research and Practice
    Volume198
    Issue number7
    DOIs
    Publication statusPublished - 2002

    Keywords

    • Bcl-2
    • Fas (APO-1)
    • FasL
    • M30 CytoDeath
    • Thymic epithelial tumors
    • Thymus

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Cell Biology

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