Apoptosis is induced by Hantaviruses in cultured cells

Ju Il Kang, Se Hoon Park, Pyung Woo Lee, Byung-Yoon Ahn

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Hantaviruses replicate in primary and cultured animal cells with little or no cytopathic effect. We report here that the cultured Vero E6 cells infected by the Hantaan or by the Prospect Hill viruses exhibited characteristic features of apoptosis, including condensation and segmentation of nuclei and internucleosomal cleavage of nuclear DNA. Apoptosis was not seen in the cells adsorbed by UV-inactivated virus, indicating that the viral replication is required for the induction of apoptosis. Furthermore, level of the proto-oncogenic Bcl-2 protein was significantly reduced, whereas its mRNA level remained unchanged in Hantaan virus-infected cells, suggesting possible involvement and posttranscriptional regulation of this antiapoptotic protein in the process.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalVirology
Volume264
Issue number1
DOIs
Publication statusPublished - 1999 Nov 10

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Hantavirus
Cultured Cells
Apoptosis
Hantaan virus
Viruses
DNA Cleavage
Vero Cells
Proteins
Messenger RNA

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Apoptosis is induced by Hantaviruses in cultured cells. / Kang, Ju Il; Park, Se Hoon; Lee, Pyung Woo; Ahn, Byung-Yoon.

In: Virology, Vol. 264, No. 1, 10.11.1999, p. 99-105.

Research output: Contribution to journalArticle

Kang, Ju Il ; Park, Se Hoon ; Lee, Pyung Woo ; Ahn, Byung-Yoon. / Apoptosis is induced by Hantaviruses in cultured cells. In: Virology. 1999 ; Vol. 264, No. 1. pp. 99-105.
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