Apoptotic signaling pathways

Caspases and stress-activated protein kinases

Ssang G. Cho, Eui Ju Choi

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor proteins such as TRADD and FADD, and caspase-8, while activation of the other from mitochondria requires Apaf-1, caspase-9, and cytosolic cytochrome c. On the other hand, persistent stimulation of the stress-activated protein kinase pathway is also shown to mediate apoptosis in many cell types. Gene-targeting studies with jnk- or jip-null mice, in particular, strongly suggest that this signaling pathway plays a pivotal role in the cellular machinery for apoptosis.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalJournal of Biochemistry and Molecular Biology
Volume35
Issue number1
Publication statusPublished - 2002 Jan 31

Fingerprint

Mitochondria
Caspases
Heat-Shock Proteins
Protein Kinases
Chemical activation
Apoptosis
Caspase 9
Caspase 8
Cell death
Cytochromes c
Machinery
Gene Targeting
Genes
Membranes
Cell Death
Proteins

Keywords

  • Apoptosis
  • Caspases
  • Stress-activated protein kinases

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Apoptotic signaling pathways : Caspases and stress-activated protein kinases. / Cho, Ssang G.; Choi, Eui Ju.

In: Journal of Biochemistry and Molecular Biology, Vol. 35, No. 1, 31.01.2002, p. 24-27.

Research output: Contribution to journalArticle

@article{dbe1c45288b04ec6b8316f0250698838,
title = "Apoptotic signaling pathways: Caspases and stress-activated protein kinases",
abstract = "Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor proteins such as TRADD and FADD, and caspase-8, while activation of the other from mitochondria requires Apaf-1, caspase-9, and cytosolic cytochrome c. On the other hand, persistent stimulation of the stress-activated protein kinase pathway is also shown to mediate apoptosis in many cell types. Gene-targeting studies with jnk- or jip-null mice, in particular, strongly suggest that this signaling pathway plays a pivotal role in the cellular machinery for apoptosis.",
keywords = "Apoptosis, Caspases, Stress-activated protein kinases",
author = "Cho, {Ssang G.} and Choi, {Eui Ju}",
year = "2002",
month = "1",
day = "31",
language = "English",
volume = "35",
pages = "24--27",
journal = "BMB Reports",
issn = "1976-6696",
publisher = "The Biochemical Society of the Republic of Korea",
number = "1",

}

TY - JOUR

T1 - Apoptotic signaling pathways

T2 - Caspases and stress-activated protein kinases

AU - Cho, Ssang G.

AU - Choi, Eui Ju

PY - 2002/1/31

Y1 - 2002/1/31

N2 - Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor proteins such as TRADD and FADD, and caspase-8, while activation of the other from mitochondria requires Apaf-1, caspase-9, and cytosolic cytochrome c. On the other hand, persistent stimulation of the stress-activated protein kinase pathway is also shown to mediate apoptosis in many cell types. Gene-targeting studies with jnk- or jip-null mice, in particular, strongly suggest that this signaling pathway plays a pivotal role in the cellular machinery for apoptosis.

AB - Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor proteins such as TRADD and FADD, and caspase-8, while activation of the other from mitochondria requires Apaf-1, caspase-9, and cytosolic cytochrome c. On the other hand, persistent stimulation of the stress-activated protein kinase pathway is also shown to mediate apoptosis in many cell types. Gene-targeting studies with jnk- or jip-null mice, in particular, strongly suggest that this signaling pathway plays a pivotal role in the cellular machinery for apoptosis.

KW - Apoptosis

KW - Caspases

KW - Stress-activated protein kinases

UR - http://www.scopus.com/inward/record.url?scp=0037203537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037203537&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 24

EP - 27

JO - BMB Reports

JF - BMB Reports

SN - 1976-6696

IS - 1

ER -