Apoptotic signaling pathways: Caspases and stress-activated protein kinases

Ssang Goo Cho, Eui Ju Choi

Research output: Contribution to journalReview article

171 Citations (Scopus)

Abstract

Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor proteins such as TRADD and FADD, and caspase-8, while activation of the other from mitochondria requires Apaf-1, caspase-9, and cytosolic cytochrome c. On the other hand, persistent stimulation of the stress-activated protein kinase pathway is also shown to mediate apoptosis in many cell types. Gene-targeting studies with jnk- or jip-null mice, in particular, strongly suggest that this signaling pathway plays a pivotal role in the cellular machinery for apoptosis.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalJournal of Biochemistry and Molecular Biology
Volume35
Issue number1
DOIs
Publication statusPublished - 2002 Jan 31

Keywords

  • Apoptosis
  • Caspases
  • Stress-activated protein kinases

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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