Applicability of interrupter resistance measurements for evaluation of exercise-induced bronchoconstriction in children

Dae-Jin Song, Chul Hee Woo, Hee Kang, Hyung Jin Kim, Ji-Tae Choung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The interrupter technique is a noninvasive method for measuring air-flow resistance during tidal breathing. This method requires minimal cooperation, and is therefore promising for use in uncooperative children. The aim of this study was to evaluate applicability interrupter resistance (Rint) measurements in the assessment of exercise-induced bronchoconstriction (EIB). Fifty children aged 5-12 years with mild to moderate asthma were tested by exercise challenge, consisting of free outdoor running for 6 min at 80-90% of maximal predicted heart rate for age. Rint, forced expiratory volume in 1 sec (FEV1), and peak expiratory flow (PEF) were measured before and 10 min after exercise. EIB was defined as a fall of 10% or more in FEV1 after exercise. The repeatability of Rint was assessed, and its response to exercise challenge was compared with current standardized methods. The mean intermeasurement coefficient of variation was 4.6% (SD, ± 3.0%), and the repeatability coefficient was 0.056 kPa/l/sec. Eighteen (36%) of the 50 children had EIB after exercise challenge test. The area under the receiver-operating characteristic (ROC) curve was 0.953 (95% confidence interval, 0.853-0.992; P < 0.001), and the optimal Rint cutoff value was 15.2%, producing a sensitivity of 88.9% and a specificity of 96.9%. The positive and negative predictive values were 94.1 % and 93.9%, respectively. The kappa value between FEV1 and Rint was 0.83. The repeatability of Rint measurements was good, and the results of exercise challenge tests using Rint measurements have excellent agreement with the current standardized methods to detect EIB. Considering that only minimal comprehension and coordination are needed without forced breathing technique, the Rint measurement can provide a useful alternative for assessment of EIB in children unable to perform reliable spirometry.

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalPediatric Pulmonology
Volume41
Issue number3
DOIs
Publication statusPublished - 2006 Mar 1

Fingerprint

Bronchoconstriction
Exercise
Forced Expiratory Volume
Exercise Test
Respiration
Spirometry
ROC Curve
Running
Asthma
Heart Rate
Air
Confidence Intervals

Keywords

  • Asthma
  • Children
  • Cutoff value
  • Exercise-induced bronchoconstriction
  • Interrupter resistance
  • Spirometry

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Applicability of interrupter resistance measurements for evaluation of exercise-induced bronchoconstriction in children. / Song, Dae-Jin; Woo, Chul Hee; Kang, Hee; Kim, Hyung Jin; Choung, Ji-Tae.

In: Pediatric Pulmonology, Vol. 41, No. 3, 01.03.2006, p. 228-233.

Research output: Contribution to journalArticle

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