Application of a pressure-relieving air compliance chamber in a single-pulsatile extracorporeal life support system

An experimental study

Sik Kim Tae, Kyung Sun, Kyu Back Lee, Hye Won Lee, Je Baek Kwang, Young Park Sung, Ho Sung Son, Taik Kim Kwang, Mook Kim Hyoung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure-relieving compliance chamber in a circuit might reduce blood cell trauma was tested. An extracorporeal life support circuit was constructed in an acute lung injury model of dogs by oleic acid infusion. The animals were divided into three groups. In group I (n = 6) a nonpulsatile centrifugal pump was used as a control. In group II (n = 4) a single-pulsatile pump was used, and in group III (n = 6) a single-pulsatile pump equipped with a compliance chamber was used. Pump flow was maintained at 1.8-2.0 L/min for 2 h. Hemodynamics and blood gas analyses indicated that the pulsatile groups II and III had better results than the nonpulsatile group I. The plasma-free hemoglobin level, which indicates blood cell trauma, was the lowest in group I and the highest in group II but was significantly decreased in group III. A pressure-relieving compliance chamber could significantly reduce high circuit pressures and blood cell trauma.

Original languageEnglish
Pages (from-to)1106-1109
Number of pages4
JournalArtificial Organs
Volume28
Issue number12
DOIs
Publication statusPublished - 2004 Dec 1

Fingerprint

Life Support Systems
Air Pressure
Extracorporeal Membrane Oxygenation
Compliance
Blood Cells
Blood
Pumps
Air
Pressure
Cells
Wounds and Injuries
Membrane Oxygenators
Networks (circuits)
Pulsatile Flow
Blood Gas Analysis
Acute Lung Injury
Oleic Acid
Oxygenators
Hemoglobins
Hemodynamics

Keywords

  • Acute lung injury
  • Artificial lung
  • Extracorporeal life support system
  • Extracorporeal membrane oxygenation

ASJC Scopus subject areas

  • Biophysics

Cite this

Application of a pressure-relieving air compliance chamber in a single-pulsatile extracorporeal life support system : An experimental study. / Tae, Sik Kim; Sun, Kyung; Lee, Kyu Back; Lee, Hye Won; Kwang, Je Baek; Sung, Young Park; Son, Ho Sung; Kwang, Taik Kim; Hyoung, Mook Kim.

In: Artificial Organs, Vol. 28, No. 12, 01.12.2004, p. 1106-1109.

Research output: Contribution to journalArticle

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