Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients

Hyemin Jang, Hee Jin Kim, Seongbeom Park, Yu Hyun Park, Yeongsim Choe, Hanna Cho, Chul Hyoung Lyoo, Uicheul Yoon, Jin San Lee, Yeshin Kim, Seung Joo Kim, Jun Pyo Kim, Young Hee Jung, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Jun Kyung Seong, Charles DeCarli, Michael W. Weiner, Samuel N. LockhartSoo Hyun Cho, Duk L. Na, Sang Won Seo

Research output: Contribution to journalArticle

Abstract

Objective: To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer’s disease (AD), and to investigate its clinical significance. Methods: We recruited 60 SVCI patients who underwent the neuropsychological tests, brain MRI, and 18F-florbetaben and 18F-AV1451 PET at baseline. As a control group, we further recruited 27 patients with AD cognitive impairment (ADCI; eight Aβ PET-positive AD dementia and 19 amnestic mild cognitive impairment). ADCI and SVCI patients were classified as having normal or abnormal Aβ (A−/A+) and tau (T−/T+) based on PET results. Across the three SVCI groups (A−, A+T−, and A+T+SVCI), we compared longitudinal changes in cognition, hippocampal volume (HV), and cortical thickness using linear mixed models. Results: Among SVCI patients, 33 (55%), 20 (33.3%), and seven (11.7%) patients were A−, A+T−, and A+T+, respectively. The frequency of T+ was lower in A+SVCI (7/27, 25.9%) than in A+ADCI (14/20, 70.0%, p = 0.003) which suggested that cerebral small vessel disease affected cognitive impairments independently of A+. A+T−SVCI had steeper cognitive decline than A−SVCI. A+T+SVCI also showed steeper cognitive decline than A+T−SVCI. Also, A+T−SVCI had steeper decrease in HV than A−SVCI, while cortical thinning did not differ between the two groups. A+T+SVCI had greater global cortical thinning compared with A+T−SVCI, while declines in HV did not differ between the two groups. Conclusion: This study showed that the AT system successfully characterized SVCI patients, suggesting that the AT system may be usefully applied in a research framework for clinically diagnosed SVCI.

Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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Amyloid
Blood Vessels
Alzheimer Disease
Cognitive Dysfunction
Cerebral Small Vessel Diseases
Neuropsychological Tests
Cognition
Linear Models

Keywords

  • Amyloid-β
  • Classification
  • Longitudinal changes
  • Subcortical vascular cognitive impairment
  • Tau

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients. / Jang, Hyemin; Kim, Hee Jin; Park, Seongbeom; Park, Yu Hyun; Choe, Yeongsim; Cho, Hanna; Lyoo, Chul Hyoung; Yoon, Uicheul; Lee, Jin San; Kim, Yeshin; Kim, Seung Joo; Kim, Jun Pyo; Jung, Young Hee; Ryu, Young Hoon; Choi, Jae Yong; Moon, Seung Hwan; Seong, Jun Kyung; DeCarli, Charles; Weiner, Michael W.; Lockhart, Samuel N.; Cho, Soo Hyun; Na, Duk L.; Seo, Sang Won.

In: European Journal of Nuclear Medicine and Molecular Imaging, 01.01.2019.

Research output: Contribution to journalArticle

Jang, H, Kim, HJ, Park, S, Park, YH, Choe, Y, Cho, H, Lyoo, CH, Yoon, U, Lee, JS, Kim, Y, Kim, SJ, Kim, JP, Jung, YH, Ryu, YH, Choi, JY, Moon, SH, Seong, JK, DeCarli, C, Weiner, MW, Lockhart, SN, Cho, SH, Na, DL & Seo, SW 2019, 'Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients', European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-019-04498-y
Jang, Hyemin ; Kim, Hee Jin ; Park, Seongbeom ; Park, Yu Hyun ; Choe, Yeongsim ; Cho, Hanna ; Lyoo, Chul Hyoung ; Yoon, Uicheul ; Lee, Jin San ; Kim, Yeshin ; Kim, Seung Joo ; Kim, Jun Pyo ; Jung, Young Hee ; Ryu, Young Hoon ; Choi, Jae Yong ; Moon, Seung Hwan ; Seong, Jun Kyung ; DeCarli, Charles ; Weiner, Michael W. ; Lockhart, Samuel N. ; Cho, Soo Hyun ; Na, Duk L. ; Seo, Sang Won. / Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients. In: European Journal of Nuclear Medicine and Molecular Imaging. 2019.
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abstract = "Objective: To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer’s disease (AD), and to investigate its clinical significance. Methods: We recruited 60 SVCI patients who underwent the neuropsychological tests, brain MRI, and 18F-florbetaben and 18F-AV1451 PET at baseline. As a control group, we further recruited 27 patients with AD cognitive impairment (ADCI; eight Aβ PET-positive AD dementia and 19 amnestic mild cognitive impairment). ADCI and SVCI patients were classified as having normal or abnormal Aβ (A−/A+) and tau (T−/T+) based on PET results. Across the three SVCI groups (A−, A+T−, and A+T+SVCI), we compared longitudinal changes in cognition, hippocampal volume (HV), and cortical thickness using linear mixed models. Results: Among SVCI patients, 33 (55{\%}), 20 (33.3{\%}), and seven (11.7{\%}) patients were A−, A+T−, and A+T+, respectively. The frequency of T+ was lower in A+SVCI (7/27, 25.9{\%}) than in A+ADCI (14/20, 70.0{\%}, p = 0.003) which suggested that cerebral small vessel disease affected cognitive impairments independently of A+. A+T−SVCI had steeper cognitive decline than A−SVCI. A+T+SVCI also showed steeper cognitive decline than A+T−SVCI. Also, A+T−SVCI had steeper decrease in HV than A−SVCI, while cortical thinning did not differ between the two groups. A+T+SVCI had greater global cortical thinning compared with A+T−SVCI, while declines in HV did not differ between the two groups. Conclusion: This study showed that the AT system successfully characterized SVCI patients, suggesting that the AT system may be usefully applied in a research framework for clinically diagnosed SVCI.",
keywords = "Amyloid-β, Classification, Longitudinal changes, Subcortical vascular cognitive impairment, Tau",
author = "Hyemin Jang and Kim, {Hee Jin} and Seongbeom Park and Park, {Yu Hyun} and Yeongsim Choe and Hanna Cho and Lyoo, {Chul Hyoung} and Uicheul Yoon and Lee, {Jin San} and Yeshin Kim and Kim, {Seung Joo} and Kim, {Jun Pyo} and Jung, {Young Hee} and Ryu, {Young Hoon} and Choi, {Jae Yong} and Moon, {Seung Hwan} and Seong, {Jun Kyung} and Charles DeCarli and Weiner, {Michael W.} and Lockhart, {Samuel N.} and Cho, {Soo Hyun} and Na, {Duk L.} and Seo, {Sang Won}",
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T1 - Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients

AU - Jang, Hyemin

AU - Kim, Hee Jin

AU - Park, Seongbeom

AU - Park, Yu Hyun

AU - Choe, Yeongsim

AU - Cho, Hanna

AU - Lyoo, Chul Hyoung

AU - Yoon, Uicheul

AU - Lee, Jin San

AU - Kim, Yeshin

AU - Kim, Seung Joo

AU - Kim, Jun Pyo

AU - Jung, Young Hee

AU - Ryu, Young Hoon

AU - Choi, Jae Yong

AU - Moon, Seung Hwan

AU - Seong, Jun Kyung

AU - DeCarli, Charles

AU - Weiner, Michael W.

AU - Lockhart, Samuel N.

AU - Cho, Soo Hyun

AU - Na, Duk L.

AU - Seo, Sang Won

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer’s disease (AD), and to investigate its clinical significance. Methods: We recruited 60 SVCI patients who underwent the neuropsychological tests, brain MRI, and 18F-florbetaben and 18F-AV1451 PET at baseline. As a control group, we further recruited 27 patients with AD cognitive impairment (ADCI; eight Aβ PET-positive AD dementia and 19 amnestic mild cognitive impairment). ADCI and SVCI patients were classified as having normal or abnormal Aβ (A−/A+) and tau (T−/T+) based on PET results. Across the three SVCI groups (A−, A+T−, and A+T+SVCI), we compared longitudinal changes in cognition, hippocampal volume (HV), and cortical thickness using linear mixed models. Results: Among SVCI patients, 33 (55%), 20 (33.3%), and seven (11.7%) patients were A−, A+T−, and A+T+, respectively. The frequency of T+ was lower in A+SVCI (7/27, 25.9%) than in A+ADCI (14/20, 70.0%, p = 0.003) which suggested that cerebral small vessel disease affected cognitive impairments independently of A+. A+T−SVCI had steeper cognitive decline than A−SVCI. A+T+SVCI also showed steeper cognitive decline than A+T−SVCI. Also, A+T−SVCI had steeper decrease in HV than A−SVCI, while cortical thinning did not differ between the two groups. A+T+SVCI had greater global cortical thinning compared with A+T−SVCI, while declines in HV did not differ between the two groups. Conclusion: This study showed that the AT system successfully characterized SVCI patients, suggesting that the AT system may be usefully applied in a research framework for clinically diagnosed SVCI.

AB - Objective: To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer’s disease (AD), and to investigate its clinical significance. Methods: We recruited 60 SVCI patients who underwent the neuropsychological tests, brain MRI, and 18F-florbetaben and 18F-AV1451 PET at baseline. As a control group, we further recruited 27 patients with AD cognitive impairment (ADCI; eight Aβ PET-positive AD dementia and 19 amnestic mild cognitive impairment). ADCI and SVCI patients were classified as having normal or abnormal Aβ (A−/A+) and tau (T−/T+) based on PET results. Across the three SVCI groups (A−, A+T−, and A+T+SVCI), we compared longitudinal changes in cognition, hippocampal volume (HV), and cortical thickness using linear mixed models. Results: Among SVCI patients, 33 (55%), 20 (33.3%), and seven (11.7%) patients were A−, A+T−, and A+T+, respectively. The frequency of T+ was lower in A+SVCI (7/27, 25.9%) than in A+ADCI (14/20, 70.0%, p = 0.003) which suggested that cerebral small vessel disease affected cognitive impairments independently of A+. A+T−SVCI had steeper cognitive decline than A−SVCI. A+T+SVCI also showed steeper cognitive decline than A+T−SVCI. Also, A+T−SVCI had steeper decrease in HV than A−SVCI, while cortical thinning did not differ between the two groups. A+T+SVCI had greater global cortical thinning compared with A+T−SVCI, while declines in HV did not differ between the two groups. Conclusion: This study showed that the AT system successfully characterized SVCI patients, suggesting that the AT system may be usefully applied in a research framework for clinically diagnosed SVCI.

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KW - Classification

KW - Longitudinal changes

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