Application of independent component analysis for the data mining of simultaneous eegfMRI: Preliminary experience on sleep onset

Jong-Hwan Lee, Sungsuk Oh, Ferenc A. Jolesz, Hyunwook Park, Seung Schik Yoo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The simultaneous acquisition of electroencephalogram (EEG) and functional MRI (fMRI) signals is potentially advantageous because of the superior resolution that is achieved in both the temporal and spatial domains, respectively. However, ballistocardiographic artifacts along with ocular artifacts are a major obstacle for the detection of the EEG signatures of interest. Since the sources corresponding to these artifacts are independent from those producing the EEG signatures, we applied the Infomax-based independent component analysis (ICA) technique to separate the EEG signatures from the artifacts. The isolated EEG signatures were further utilized to model the canonical hemodynamic response functions (HRFs). Subsequently, the brain areas from which these EEG signatures originated were identified as locales of activation patterns from the analysis of fMRI data. Upon the identification and subsequent evaluation of brain areas generating interictal epileptic discharge (IED) spikes from an epileptic subject, the presented method was successfully applied to detect the theta and alpha rhythms that are sleep onset-related EEG signatures along with the subsequent neural circuitries from a sleep-deprived volunteer. These results suggest that the ICA technique may be useful for the preprocessing of simultaneous EEGfMRI acquisitions, especially when a reference paradigm is unavailable.

Original languageEnglish
Pages (from-to)1118-1136
Number of pages19
JournalInternational Journal of Neuroscience
Volume119
Issue number8
DOIs
Publication statusPublished - 2009 Nov 4
Externally publishedYes

Fingerprint

Data Mining
Electroencephalography
Sleep
Artifacts
Magnetic Resonance Imaging
Alpha Rhythm
Theta Rhythm
Activation Analysis
Brain
Volunteers
Hemodynamics

Keywords

  • Electroencephalogram (EEG)
  • Epileptic discharge
  • Functional MRI (fMRI)
  • Independent component analysis (ICA)
  • Simultaneous EEGfMRI
  • Sleep pattern

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Application of independent component analysis for the data mining of simultaneous eegfMRI : Preliminary experience on sleep onset. / Lee, Jong-Hwan; Oh, Sungsuk; Jolesz, Ferenc A.; Park, Hyunwook; Yoo, Seung Schik.

In: International Journal of Neuroscience, Vol. 119, No. 8, 04.11.2009, p. 1118-1136.

Research output: Contribution to journalArticle

Lee, Jong-Hwan ; Oh, Sungsuk ; Jolesz, Ferenc A. ; Park, Hyunwook ; Yoo, Seung Schik. / Application of independent component analysis for the data mining of simultaneous eegfMRI : Preliminary experience on sleep onset. In: International Journal of Neuroscience. 2009 ; Vol. 119, No. 8. pp. 1118-1136.
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