Application of the HALF index obviates the need for liver biopsy in half of all patients with chronic hepatitis B

Hyun Jung Lee, Yeon Seok Seo, Dong Jin Kim, Hyun Seok Kang, Hyonggin An, Ji Hoon Kim, Jae Youn Cheong, Hyung Joon Yim, Jong Eun Yeon, Hong Sik Lee, Kwan Soo Byun, Sung Won Cho, Dong Joon Kim, Soon-Ho Um, Chang Duck Kim, Ho Sang Ryu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and Aims: Transient elastography (TE) is useful for predicting the fibrosis stage, but it is unsatisfactory as a substitute for liver biopsy, especially in patients with chronic hepatitis B (CHB). This study was performed to establish a reliable model for predicting significant fibrosis (SF) in patients with CHB. Methods: All CHB patients who were admitted to undergo liver biopsy were enrolled. They were randomly classified into either a training set (n=139) or a validation set (n=69). A model for predicting SF was established in the training set and validated in the validation set. Low and high cutoff values (COVs) were chosen for sensitivity ≥99% and specificity ≥99%, respectively. Results: A total of 208 patients were enrolled. Age was 39±12years and 149 (71.6%) were men. In the training set, liver stiffness values and serum haptoglobin, apolipoprotein A1, and α2-macroglobulin levels were independent predictors of SF on multivariate analysis. These variables were used to construct a novel model, called the HALF index. The area under the receiver operating characteristics curve of the HALF index for predicting SF was significantly higher than that of TE alone (0.915 vs 0.877, P=0.010). Using low and high COVs of the HALF index, it appears that approximately half (47.1%) of patients could avoid liver biopsy, with an associated accuracy of 99.0%. Conclusion: A combination of liver stiffness and serum markers identified SF with a high degree of accuracy. Approximately half of all patients with CHB could avoid liver biopsy through the utilization of the HALF index.

Original languageEnglish
Pages (from-to)987-995
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number6
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Chronic Hepatitis B
Fibrosis
Biopsy
Liver
Elasticity Imaging Techniques
Macroglobulins
Haptoglobins
Apolipoprotein A-I
ROC Curve
Multivariate Analysis
Biomarkers
Sensitivity and Specificity
Serum

Keywords

  • Apolipoprotein
  • Elastography
  • Fibrosis
  • Haptoglobin
  • Macroglobulin

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Application of the HALF index obviates the need for liver biopsy in half of all patients with chronic hepatitis B. / Lee, Hyun Jung; Seo, Yeon Seok; Kim, Dong Jin; Kang, Hyun Seok; An, Hyonggin; Kim, Ji Hoon; Cheong, Jae Youn; Yim, Hyung Joon; Yeon, Jong Eun; Lee, Hong Sik; Byun, Kwan Soo; Cho, Sung Won; Kim, Dong Joon; Um, Soon-Ho; Kim, Chang Duck; Ryu, Ho Sang.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 26, No. 6, 01.01.2011, p. 987-995.

Research output: Contribution to journalArticle

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abstract = "Background and Aims: Transient elastography (TE) is useful for predicting the fibrosis stage, but it is unsatisfactory as a substitute for liver biopsy, especially in patients with chronic hepatitis B (CHB). This study was performed to establish a reliable model for predicting significant fibrosis (SF) in patients with CHB. Methods: All CHB patients who were admitted to undergo liver biopsy were enrolled. They were randomly classified into either a training set (n=139) or a validation set (n=69). A model for predicting SF was established in the training set and validated in the validation set. Low and high cutoff values (COVs) were chosen for sensitivity ≥99{\%} and specificity ≥99{\%}, respectively. Results: A total of 208 patients were enrolled. Age was 39±12years and 149 (71.6{\%}) were men. In the training set, liver stiffness values and serum haptoglobin, apolipoprotein A1, and α2-macroglobulin levels were independent predictors of SF on multivariate analysis. These variables were used to construct a novel model, called the HALF index. The area under the receiver operating characteristics curve of the HALF index for predicting SF was significantly higher than that of TE alone (0.915 vs 0.877, P=0.010). Using low and high COVs of the HALF index, it appears that approximately half (47.1{\%}) of patients could avoid liver biopsy, with an associated accuracy of 99.0{\%}. Conclusion: A combination of liver stiffness and serum markers identified SF with a high degree of accuracy. Approximately half of all patients with CHB could avoid liver biopsy through the utilization of the HALF index.",
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AU - Lee, Hyun Jung

AU - Seo, Yeon Seok

AU - Kim, Dong Jin

AU - Kang, Hyun Seok

AU - An, Hyonggin

AU - Kim, Ji Hoon

AU - Cheong, Jae Youn

AU - Yim, Hyung Joon

AU - Yeon, Jong Eun

AU - Lee, Hong Sik

AU - Byun, Kwan Soo

AU - Cho, Sung Won

AU - Kim, Dong Joon

AU - Um, Soon-Ho

AU - Kim, Chang Duck

AU - Ryu, Ho Sang

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AB - Background and Aims: Transient elastography (TE) is useful for predicting the fibrosis stage, but it is unsatisfactory as a substitute for liver biopsy, especially in patients with chronic hepatitis B (CHB). This study was performed to establish a reliable model for predicting significant fibrosis (SF) in patients with CHB. Methods: All CHB patients who were admitted to undergo liver biopsy were enrolled. They were randomly classified into either a training set (n=139) or a validation set (n=69). A model for predicting SF was established in the training set and validated in the validation set. Low and high cutoff values (COVs) were chosen for sensitivity ≥99% and specificity ≥99%, respectively. Results: A total of 208 patients were enrolled. Age was 39±12years and 149 (71.6%) were men. In the training set, liver stiffness values and serum haptoglobin, apolipoprotein A1, and α2-macroglobulin levels were independent predictors of SF on multivariate analysis. These variables were used to construct a novel model, called the HALF index. The area under the receiver operating characteristics curve of the HALF index for predicting SF was significantly higher than that of TE alone (0.915 vs 0.877, P=0.010). Using low and high COVs of the HALF index, it appears that approximately half (47.1%) of patients could avoid liver biopsy, with an associated accuracy of 99.0%. Conclusion: A combination of liver stiffness and serum markers identified SF with a high degree of accuracy. Approximately half of all patients with CHB could avoid liver biopsy through the utilization of the HALF index.

KW - Apolipoprotein

KW - Elastography

KW - Fibrosis

KW - Haptoglobin

KW - Macroglobulin

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