Application of two different synthetic sequential media for the human IVF-ET program

A prospective, randomized, and comparative study

Jeong Yoon, Hye Jin Yoon, Kyoung Mi Juhn, Jin Kyung Ko, San Hyun Yoon, Yong Ko, Jin Ho Lim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: Since IVF program was first established, various types of media and culture systems have been developed either in-house or commercially. The aim of this study was to compare the efficacy of in-house Maria Research Center (MRC) media to that of commercially available Sydney IVF media in human day 3 embryo transfer cycles.Methods: Three hundred sixty nine couples were included in this prospective, randomized, and comparative study. All couples undergoing IVF treatment at the Maria Fertility Hospital were randomly assigned to either Sydney IVF (n=178) or MRC (n=191) media.Results: No difference was observed between the MRC media and Sydney IVF media groups with respect to fertilization rate (74.4% vs. 75.5%). The clinical pregnancy and implantation rates of MRC media (47.1% and 20.0%, respectively) were also similar to those of Sydney IVF media (44.4% and 19.4%, respectively). However, the proportion of embryos with good quality on day 3 was significantly higher in the MRC media group than the Sydney IVF media group (50.2% vs. 43.2%) (p<0.05).Conclusion: MRC media were as effective as Sydney IVF media for sustaining embryo development and pregnancy rates. The present study implies that MRC media can be a suitable alternative to commercially available media for human IVF-ET program.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalClinical and Experimental Reproductive Medicine
Volume38
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Research
Pregnancy Rate
Embryo Transfer
Fertilization
Embryonic Development
Fertility
Culture Media
Embryonic Structures
Therapeutics

Keywords

  • Day 3 embryo transfer
  • Human
  • In vitro fertilization-embryo transfer
  • MRC media
  • Sydney IVF media

ASJC Scopus subject areas

  • Reproductive Medicine

Cite this

Application of two different synthetic sequential media for the human IVF-ET program : A prospective, randomized, and comparative study. / Yoon, Jeong; Yoon, Hye Jin; Juhn, Kyoung Mi; Ko, Jin Kyung; Yoon, San Hyun; Ko, Yong; Lim, Jin Ho.

In: Clinical and Experimental Reproductive Medicine, Vol. 38, No. 4, 01.12.2011, p. 186-192.

Research output: Contribution to journalArticle

Yoon, Jeong ; Yoon, Hye Jin ; Juhn, Kyoung Mi ; Ko, Jin Kyung ; Yoon, San Hyun ; Ko, Yong ; Lim, Jin Ho. / Application of two different synthetic sequential media for the human IVF-ET program : A prospective, randomized, and comparative study. In: Clinical and Experimental Reproductive Medicine. 2011 ; Vol. 38, No. 4. pp. 186-192.
@article{709b9fe870864cc9add845c249f1e67a,
title = "Application of two different synthetic sequential media for the human IVF-ET program: A prospective, randomized, and comparative study",
abstract = "Objective: Since IVF program was first established, various types of media and culture systems have been developed either in-house or commercially. The aim of this study was to compare the efficacy of in-house Maria Research Center (MRC) media to that of commercially available Sydney IVF media in human day 3 embryo transfer cycles.Methods: Three hundred sixty nine couples were included in this prospective, randomized, and comparative study. All couples undergoing IVF treatment at the Maria Fertility Hospital were randomly assigned to either Sydney IVF (n=178) or MRC (n=191) media.Results: No difference was observed between the MRC media and Sydney IVF media groups with respect to fertilization rate (74.4{\%} vs. 75.5{\%}). The clinical pregnancy and implantation rates of MRC media (47.1{\%} and 20.0{\%}, respectively) were also similar to those of Sydney IVF media (44.4{\%} and 19.4{\%}, respectively). However, the proportion of embryos with good quality on day 3 was significantly higher in the MRC media group than the Sydney IVF media group (50.2{\%} vs. 43.2{\%}) (p<0.05).Conclusion: MRC media were as effective as Sydney IVF media for sustaining embryo development and pregnancy rates. The present study implies that MRC media can be a suitable alternative to commercially available media for human IVF-ET program.",
keywords = "Day 3 embryo transfer, Human, In vitro fertilization-embryo transfer, MRC media, Sydney IVF media",
author = "Jeong Yoon and Yoon, {Hye Jin} and Juhn, {Kyoung Mi} and Ko, {Jin Kyung} and Yoon, {San Hyun} and Yong Ko and Lim, {Jin Ho}",
year = "2011",
month = "12",
day = "1",
doi = "10.5653/cerm.2011.38.4.186",
language = "English",
volume = "38",
pages = "186--192",
journal = "Clinical and Experimental Reproductive Medicine",
issn = "2233-8233",
publisher = "Korean Society for Reproductive Medicine",
number = "4",

}

TY - JOUR

T1 - Application of two different synthetic sequential media for the human IVF-ET program

T2 - A prospective, randomized, and comparative study

AU - Yoon, Jeong

AU - Yoon, Hye Jin

AU - Juhn, Kyoung Mi

AU - Ko, Jin Kyung

AU - Yoon, San Hyun

AU - Ko, Yong

AU - Lim, Jin Ho

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Objective: Since IVF program was first established, various types of media and culture systems have been developed either in-house or commercially. The aim of this study was to compare the efficacy of in-house Maria Research Center (MRC) media to that of commercially available Sydney IVF media in human day 3 embryo transfer cycles.Methods: Three hundred sixty nine couples were included in this prospective, randomized, and comparative study. All couples undergoing IVF treatment at the Maria Fertility Hospital were randomly assigned to either Sydney IVF (n=178) or MRC (n=191) media.Results: No difference was observed between the MRC media and Sydney IVF media groups with respect to fertilization rate (74.4% vs. 75.5%). The clinical pregnancy and implantation rates of MRC media (47.1% and 20.0%, respectively) were also similar to those of Sydney IVF media (44.4% and 19.4%, respectively). However, the proportion of embryos with good quality on day 3 was significantly higher in the MRC media group than the Sydney IVF media group (50.2% vs. 43.2%) (p<0.05).Conclusion: MRC media were as effective as Sydney IVF media for sustaining embryo development and pregnancy rates. The present study implies that MRC media can be a suitable alternative to commercially available media for human IVF-ET program.

AB - Objective: Since IVF program was first established, various types of media and culture systems have been developed either in-house or commercially. The aim of this study was to compare the efficacy of in-house Maria Research Center (MRC) media to that of commercially available Sydney IVF media in human day 3 embryo transfer cycles.Methods: Three hundred sixty nine couples were included in this prospective, randomized, and comparative study. All couples undergoing IVF treatment at the Maria Fertility Hospital were randomly assigned to either Sydney IVF (n=178) or MRC (n=191) media.Results: No difference was observed between the MRC media and Sydney IVF media groups with respect to fertilization rate (74.4% vs. 75.5%). The clinical pregnancy and implantation rates of MRC media (47.1% and 20.0%, respectively) were also similar to those of Sydney IVF media (44.4% and 19.4%, respectively). However, the proportion of embryos with good quality on day 3 was significantly higher in the MRC media group than the Sydney IVF media group (50.2% vs. 43.2%) (p<0.05).Conclusion: MRC media were as effective as Sydney IVF media for sustaining embryo development and pregnancy rates. The present study implies that MRC media can be a suitable alternative to commercially available media for human IVF-ET program.

KW - Day 3 embryo transfer

KW - Human

KW - In vitro fertilization-embryo transfer

KW - MRC media

KW - Sydney IVF media

UR - http://www.scopus.com/inward/record.url?scp=84864605866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864605866&partnerID=8YFLogxK

U2 - 10.5653/cerm.2011.38.4.186

DO - 10.5653/cerm.2011.38.4.186

M3 - Article

VL - 38

SP - 186

EP - 192

JO - Clinical and Experimental Reproductive Medicine

JF - Clinical and Experimental Reproductive Medicine

SN - 2233-8233

IS - 4

ER -