Application of two different synthetic sequential media for the human IVF-ET program: A prospective, randomized, and comparative study

Jeong Yoon, Hye Jin Yoon, Kyoung Mi Juhn, Jin Kyung Ko, San Hyun Yoon, Yong Ko, Jin Ho Lim

Research output: Contribution to journalArticle

10 Citations (Scopus)


Objective: Since IVF program was first established, various types of media and culture systems have been developed either in-house or commercially. The aim of this study was to compare the efficacy of in-house Maria Research Center (MRC) media to that of commercially available Sydney IVF media in human day 3 embryo transfer cycles.Methods: Three hundred sixty nine couples were included in this prospective, randomized, and comparative study. All couples undergoing IVF treatment at the Maria Fertility Hospital were randomly assigned to either Sydney IVF (n=178) or MRC (n=191) media.Results: No difference was observed between the MRC media and Sydney IVF media groups with respect to fertilization rate (74.4% vs. 75.5%). The clinical pregnancy and implantation rates of MRC media (47.1% and 20.0%, respectively) were also similar to those of Sydney IVF media (44.4% and 19.4%, respectively). However, the proportion of embryos with good quality on day 3 was significantly higher in the MRC media group than the Sydney IVF media group (50.2% vs. 43.2%) (p<0.05).Conclusion: MRC media were as effective as Sydney IVF media for sustaining embryo development and pregnancy rates. The present study implies that MRC media can be a suitable alternative to commercially available media for human IVF-ET program.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalClinical and Experimental Reproductive Medicine
Issue number4
Publication statusPublished - 2011 Dec 1



  • Day 3 embryo transfer
  • Human
  • In vitro fertilization-embryo transfer
  • MRC media
  • Sydney IVF media

ASJC Scopus subject areas

  • Reproductive Medicine

Cite this