Applications of the pulsatile flow versatile ECLS

In vivo studies

Y. R. Rho, Hyuk Choi, J. C. Lee, S. W. Choi, Y. M. Chung, H. S. Lee, C. M. Hwang, H. S. Lee, S. S. Ahn, R. Y. Lee, Ho Sung Son, M. J. Choi, K. J. Baek, J. S. Kim, G. J. Suh, Y. S. Won, Kyung Sun, Byoung Goo Min

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Introduction: T-PLS (Twin-Pulse Life Support) is the first commercial pulsatile ECLS (Extra Corporeal Life Support) device (1). The dual sac structure of T-PLS can effectively reduce high membrane oxygenator inlet pressure and hemolysis. To verify both the use of T-PLS for ECLS and the advantages of T-PLS, we tested various models. Method and results: In the partial CPB (cardio pulmonary bypass) model (swine), T-PLS (N=6), and Biopump (N=2), a single pulsatile pump (N=2), were compared. In the case of single pulsatile flow, during pump systole, pressure increased to 700 - 800 mmHg at the inlet port of the membrane oxygenator. fHb, a hemolysis measurement value, was about 80 mg/dL at 3 hours. On the contrary, because of T-PLS's dual sac system, the pressure of T-PLS had a maximum value of about 250 mmHg and fHb was similar to that of the commercial centrifugal pumps. In the total CPB model (bovine, N=6), the heart was stopped via cardioplegia (Kcl). T-PLS flow was maintained at 3.0 - 4.5 L/min. T-PLS functioned like a natural heart, having a pulse pressure of 26 - 43 mmHg and a pulse rate of 40 - 60 bpm (beats per minute). In the emergency case model (canine, N=6), T-PLS was started 10 minutes after cardiac arrest from electronic shock. In spite of cardiac arrest for a period of 40 minutes, the heart was recovered after defibrillation. In the ARDS (Acute Respiratory Distress Syndrome) model (canine, N=6), minimal ventilator parameters were set: tidal volume 130 ml, respiration rate = bpm, FiO2 = 10%. Three hours after starting T-PLS, PO2 of the carotid artery blood (after 2 hours: 195 ± 89.4; after 3 hours: 258 ± 99.3 mmHg) was above half the value of the femoral artery but was within normal range. Conclusion: It is suggested that a portable pulsatile ECLS like T-PLS may be used as a CPB device and as an alternative CPR (cardiopulmonary resuscitation) device in the case of cardiac arrest. Due to the pulsatile flow, oxygenated blood is delivered to the patient without overloading the ARDS patient's heart.

Original languageEnglish
Pages (from-to)428-435
Number of pages8
JournalInternational Journal of Artificial Organs
Volume26
Issue number5
Publication statusPublished - 2003 May 1

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Pulsatile Flow
Pulsatile flow
Pulse
Oxygenators
Blood
Pumps
Resuscitation
Membranes
Centrifugal pumps
Heart Arrest
Membrane Oxygenators
Adult Respiratory Distress Syndrome
Hemolysis
Equipment and Supplies
Lung
Canidae
Blood Pressure
Pressure
Induced Heart Arrest
Systole

ASJC Scopus subject areas

  • Biophysics

Cite this

Rho, Y. R., Choi, H., Lee, J. C., Choi, S. W., Chung, Y. M., Lee, H. S., ... Min, B. G. (2003). Applications of the pulsatile flow versatile ECLS: In vivo studies. International Journal of Artificial Organs, 26(5), 428-435.

Applications of the pulsatile flow versatile ECLS : In vivo studies. / Rho, Y. R.; Choi, Hyuk; Lee, J. C.; Choi, S. W.; Chung, Y. M.; Lee, H. S.; Hwang, C. M.; Lee, H. S.; Ahn, S. S.; Lee, R. Y.; Son, Ho Sung; Choi, M. J.; Baek, K. J.; Kim, J. S.; Suh, G. J.; Won, Y. S.; Sun, Kyung; Min, Byoung Goo.

In: International Journal of Artificial Organs, Vol. 26, No. 5, 01.05.2003, p. 428-435.

Research output: Contribution to journalArticle

Rho, YR, Choi, H, Lee, JC, Choi, SW, Chung, YM, Lee, HS, Hwang, CM, Lee, HS, Ahn, SS, Lee, RY, Son, HS, Choi, MJ, Baek, KJ, Kim, JS, Suh, GJ, Won, YS, Sun, K & Min, BG 2003, 'Applications of the pulsatile flow versatile ECLS: In vivo studies', International Journal of Artificial Organs, vol. 26, no. 5, pp. 428-435.
Rho YR, Choi H, Lee JC, Choi SW, Chung YM, Lee HS et al. Applications of the pulsatile flow versatile ECLS: In vivo studies. International Journal of Artificial Organs. 2003 May 1;26(5):428-435.
Rho, Y. R. ; Choi, Hyuk ; Lee, J. C. ; Choi, S. W. ; Chung, Y. M. ; Lee, H. S. ; Hwang, C. M. ; Lee, H. S. ; Ahn, S. S. ; Lee, R. Y. ; Son, Ho Sung ; Choi, M. J. ; Baek, K. J. ; Kim, J. S. ; Suh, G. J. ; Won, Y. S. ; Sun, Kyung ; Min, Byoung Goo. / Applications of the pulsatile flow versatile ECLS : In vivo studies. In: International Journal of Artificial Organs. 2003 ; Vol. 26, No. 5. pp. 428-435.
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T2 - In vivo studies

AU - Rho, Y. R.

AU - Choi, Hyuk

AU - Lee, J. C.

AU - Choi, S. W.

AU - Chung, Y. M.

AU - Lee, H. S.

AU - Hwang, C. M.

AU - Lee, H. S.

AU - Ahn, S. S.

AU - Lee, R. Y.

AU - Son, Ho Sung

AU - Choi, M. J.

AU - Baek, K. J.

AU - Kim, J. S.

AU - Suh, G. J.

AU - Won, Y. S.

AU - Sun, Kyung

AU - Min, Byoung Goo

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AB - Introduction: T-PLS (Twin-Pulse Life Support) is the first commercial pulsatile ECLS (Extra Corporeal Life Support) device (1). The dual sac structure of T-PLS can effectively reduce high membrane oxygenator inlet pressure and hemolysis. To verify both the use of T-PLS for ECLS and the advantages of T-PLS, we tested various models. Method and results: In the partial CPB (cardio pulmonary bypass) model (swine), T-PLS (N=6), and Biopump (N=2), a single pulsatile pump (N=2), were compared. In the case of single pulsatile flow, during pump systole, pressure increased to 700 - 800 mmHg at the inlet port of the membrane oxygenator. fHb, a hemolysis measurement value, was about 80 mg/dL at 3 hours. On the contrary, because of T-PLS's dual sac system, the pressure of T-PLS had a maximum value of about 250 mmHg and fHb was similar to that of the commercial centrifugal pumps. In the total CPB model (bovine, N=6), the heart was stopped via cardioplegia (Kcl). T-PLS flow was maintained at 3.0 - 4.5 L/min. T-PLS functioned like a natural heart, having a pulse pressure of 26 - 43 mmHg and a pulse rate of 40 - 60 bpm (beats per minute). In the emergency case model (canine, N=6), T-PLS was started 10 minutes after cardiac arrest from electronic shock. In spite of cardiac arrest for a period of 40 minutes, the heart was recovered after defibrillation. In the ARDS (Acute Respiratory Distress Syndrome) model (canine, N=6), minimal ventilator parameters were set: tidal volume 130 ml, respiration rate = bpm, FiO2 = 10%. Three hours after starting T-PLS, PO2 of the carotid artery blood (after 2 hours: 195 ± 89.4; after 3 hours: 258 ± 99.3 mmHg) was above half the value of the femoral artery but was within normal range. Conclusion: It is suggested that a portable pulsatile ECLS like T-PLS may be used as a CPB device and as an alternative CPR (cardiopulmonary resuscitation) device in the case of cardiac arrest. Due to the pulsatile flow, oxygenated blood is delivered to the patient without overloading the ARDS patient's heart.

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