Approach to cytomegalovirus infections in patients with ulcerative colitis

Sung Chul Park, Yoon Mi Jeen, Yoon Tae Jeen

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) reactivation is common in patients with severe ulcerative colitis (UC), and may ref lect exacerbation of mucosal inflammation and/or administration of immunosuppressants. The question of whether CMV is an active pathogen or ‘an innocent bystander’ in the exacerbation of UC remains controversial. Patients with UC exacerbated by reactivated CMV experience worse prognoses than those without CMV reactivation and antiviral therapy significantly reduces the need for colectomy in patients with severe UC and high-grade CMV infection, indicating that CMV plays a role in UC prognosis. Therefore, the CMV status of patients on immunosuppressants, particularly those with steroid-refractory or -dependent UC, should be tested. When CMV is detected, be performed based on should adequate treatment the extent of the viral load and the presence of certain clinical features including a large ulcer. Anti-tumor necrosis factor agents may be useful for treating CMV colitis complicating UC.

Original languageEnglish
Pages (from-to)383-392
Number of pages10
JournalKorean Journal of Internal Medicine
Volume32
Issue number3
DOIs
Publication statusPublished - 2017 May 1

Fingerprint

Cytomegalovirus Infections
Cytomegalovirus
Ulcerative Colitis
Immunosuppressive Agents
Colectomy
Colitis
Viral Load
Ulcer
Antiviral Agents
Tumor Necrosis Factor-alpha
Steroids
Inflammation
Therapeutics

Keywords

  • Colitis
  • Cytomegalovirus
  • Ulcerative

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Approach to cytomegalovirus infections in patients with ulcerative colitis. / Park, Sung Chul; Jeen, Yoon Mi; Jeen, Yoon Tae.

In: Korean Journal of Internal Medicine, Vol. 32, No. 3, 01.05.2017, p. 383-392.

Research output: Contribution to journalReview article

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abstract = "Cytomegalovirus (CMV) reactivation is common in patients with severe ulcerative colitis (UC), and may ref lect exacerbation of mucosal inflammation and/or administration of immunosuppressants. The question of whether CMV is an active pathogen or ‘an innocent bystander’ in the exacerbation of UC remains controversial. Patients with UC exacerbated by reactivated CMV experience worse prognoses than those without CMV reactivation and antiviral therapy significantly reduces the need for colectomy in patients with severe UC and high-grade CMV infection, indicating that CMV plays a role in UC prognosis. Therefore, the CMV status of patients on immunosuppressants, particularly those with steroid-refractory or -dependent UC, should be tested. When CMV is detected, be performed based on should adequate treatment the extent of the viral load and the presence of certain clinical features including a large ulcer. Anti-tumor necrosis factor agents may be useful for treating CMV colitis complicating UC.",
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