Approach to the synthesis of nogalarol via the cycloaddition of a carbene-chromium complex with a functionalized alkyne

M. F. Semmelhack, Nakcheol Jeong

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The alkyne, 4, prepared stereoselectively in 7 steps from acetyl furan, reacts with (methoxy)(phenyl)carbenepentacarbonylchromium(0), 15, to give the model (16) for nogalarol (1b) in 43% yield.

Original languageEnglish
Pages (from-to)605-608
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number5
DOIs
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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