Appropriate amount of regular exercise is associated with a reduced mortality risk

Da Young Lee, Eun Jung Rhee, Jung Hwan Cho, Hyemi Kwon, Se Eun Park, Yang-Hyun Kim, Kyungdo Han, Yong Kyu Park, Soon Jib Yoo, Won Young Lee

Research output: Contribution to journalArticle

Abstract

Purpose This study aimed at investigating whether there is a continuous dose-response relationship between the amount of physical activity (PA) and longevity benefit. Methods We evaluated the records of 23,257,723 Koreans age ≥20 yr who had undergone one biennial medical evaluation by the National Health Insurance Corporation. Participants with ≥20 min of vigorous or ≥30 min of moderate PA or walking were stratified into four groups: 0 d·wk-1; 1-3 d·wk-1; 4 to 5 d·wk-1; and 6-7 d·wk-1. After calculating total metabolic equivalent task-hours per week (MET·h·wk-1), we created eight categories of MET-hours per week (0, 0.1-4.9, 5.0-9.9, 10.0-14.9, 15.0-19.9, 20.0-24.9, 25.0-29.9, and ≥30.0). Multivariate Cox proportional hazard analyses were performed. Results A reverse J-shaped risk curve was observed, with the lowest mortality risk in the participants exercising 4 to 5 d·wk-1 (reference). Participants who did not exercise at all and those who exercised with a PA frequency of 1 to 3 d·wk-1 or 6 to 7 d·wk-1 showed a significantly increased mortality risk compared with the reference group. When we repeated the Cox analysis among the 8 MET·h·wk-1 categories with the participants reporting 20.0 to 24.9 MET·h·wk-1 of PA as the reference group, we found that those with physical inactivity and 25.0-29.9 or ≥30.0 MET·h·wk-1 of PA showed a higher mortality risk than the reference group. These relationships were persistently observed after adjustment for confounders. Conclusions An appropriate amount of regular exercise in each specific type of PA was associated with the lowest risk of mortality. The inactive participants showed an increased mortality risk, and daily PA did not show any additional benefit in the mortality risk.

Original languageEnglish
Pages (from-to)2451-2458
Number of pages8
JournalMedicine and Science in Sports and Exercise
Volume50
Issue number12
DOIs
Publication statusPublished - 2018 Dec 1

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Exercise
Mortality
Metabolic Equivalent
National Health Programs
Walking

Keywords

  • EXERCISE
  • INTERNATIONAL PHYSICAL ACTIVITY QUESTIONNAIRE
  • METABOLIC EQUIVALENT TASK
  • MORTALITY
  • PHYSICAL ACTIVITY

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Appropriate amount of regular exercise is associated with a reduced mortality risk. / Lee, Da Young; Rhee, Eun Jung; Cho, Jung Hwan; Kwon, Hyemi; Park, Se Eun; Kim, Yang-Hyun; Han, Kyungdo; Park, Yong Kyu; Yoo, Soon Jib; Lee, Won Young.

In: Medicine and Science in Sports and Exercise, Vol. 50, No. 12, 01.12.2018, p. 2451-2458.

Research output: Contribution to journalArticle

Lee, DY, Rhee, EJ, Cho, JH, Kwon, H, Park, SE, Kim, Y-H, Han, K, Park, YK, Yoo, SJ & Lee, WY 2018, 'Appropriate amount of regular exercise is associated with a reduced mortality risk', Medicine and Science in Sports and Exercise, vol. 50, no. 12, pp. 2451-2458. https://doi.org/10.1249/MSS.0000000000001734
Lee, Da Young ; Rhee, Eun Jung ; Cho, Jung Hwan ; Kwon, Hyemi ; Park, Se Eun ; Kim, Yang-Hyun ; Han, Kyungdo ; Park, Yong Kyu ; Yoo, Soon Jib ; Lee, Won Young. / Appropriate amount of regular exercise is associated with a reduced mortality risk. In: Medicine and Science in Sports and Exercise. 2018 ; Vol. 50, No. 12. pp. 2451-2458.
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abstract = "Purpose This study aimed at investigating whether there is a continuous dose-response relationship between the amount of physical activity (PA) and longevity benefit. Methods We evaluated the records of 23,257,723 Koreans age ≥20 yr who had undergone one biennial medical evaluation by the National Health Insurance Corporation. Participants with ≥20 min of vigorous or ≥30 min of moderate PA or walking were stratified into four groups: 0 d·wk-1; 1-3 d·wk-1; 4 to 5 d·wk-1; and 6-7 d·wk-1. After calculating total metabolic equivalent task-hours per week (MET·h·wk-1), we created eight categories of MET-hours per week (0, 0.1-4.9, 5.0-9.9, 10.0-14.9, 15.0-19.9, 20.0-24.9, 25.0-29.9, and ≥30.0). Multivariate Cox proportional hazard analyses were performed. Results A reverse J-shaped risk curve was observed, with the lowest mortality risk in the participants exercising 4 to 5 d·wk-1 (reference). Participants who did not exercise at all and those who exercised with a PA frequency of 1 to 3 d·wk-1 or 6 to 7 d·wk-1 showed a significantly increased mortality risk compared with the reference group. When we repeated the Cox analysis among the 8 MET·h·wk-1 categories with the participants reporting 20.0 to 24.9 MET·h·wk-1 of PA as the reference group, we found that those with physical inactivity and 25.0-29.9 or ≥30.0 MET·h·wk-1 of PA showed a higher mortality risk than the reference group. These relationships were persistently observed after adjustment for confounders. Conclusions An appropriate amount of regular exercise in each specific type of PA was associated with the lowest risk of mortality. The inactive participants showed an increased mortality risk, and daily PA did not show any additional benefit in the mortality risk.",
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T1 - Appropriate amount of regular exercise is associated with a reduced mortality risk

AU - Lee, Da Young

AU - Rhee, Eun Jung

AU - Cho, Jung Hwan

AU - Kwon, Hyemi

AU - Park, Se Eun

AU - Kim, Yang-Hyun

AU - Han, Kyungdo

AU - Park, Yong Kyu

AU - Yoo, Soon Jib

AU - Lee, Won Young

PY - 2018/12/1

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N2 - Purpose This study aimed at investigating whether there is a continuous dose-response relationship between the amount of physical activity (PA) and longevity benefit. Methods We evaluated the records of 23,257,723 Koreans age ≥20 yr who had undergone one biennial medical evaluation by the National Health Insurance Corporation. Participants with ≥20 min of vigorous or ≥30 min of moderate PA or walking were stratified into four groups: 0 d·wk-1; 1-3 d·wk-1; 4 to 5 d·wk-1; and 6-7 d·wk-1. After calculating total metabolic equivalent task-hours per week (MET·h·wk-1), we created eight categories of MET-hours per week (0, 0.1-4.9, 5.0-9.9, 10.0-14.9, 15.0-19.9, 20.0-24.9, 25.0-29.9, and ≥30.0). Multivariate Cox proportional hazard analyses were performed. Results A reverse J-shaped risk curve was observed, with the lowest mortality risk in the participants exercising 4 to 5 d·wk-1 (reference). Participants who did not exercise at all and those who exercised with a PA frequency of 1 to 3 d·wk-1 or 6 to 7 d·wk-1 showed a significantly increased mortality risk compared with the reference group. When we repeated the Cox analysis among the 8 MET·h·wk-1 categories with the participants reporting 20.0 to 24.9 MET·h·wk-1 of PA as the reference group, we found that those with physical inactivity and 25.0-29.9 or ≥30.0 MET·h·wk-1 of PA showed a higher mortality risk than the reference group. These relationships were persistently observed after adjustment for confounders. Conclusions An appropriate amount of regular exercise in each specific type of PA was associated with the lowest risk of mortality. The inactive participants showed an increased mortality risk, and daily PA did not show any additional benefit in the mortality risk.

AB - Purpose This study aimed at investigating whether there is a continuous dose-response relationship between the amount of physical activity (PA) and longevity benefit. Methods We evaluated the records of 23,257,723 Koreans age ≥20 yr who had undergone one biennial medical evaluation by the National Health Insurance Corporation. Participants with ≥20 min of vigorous or ≥30 min of moderate PA or walking were stratified into four groups: 0 d·wk-1; 1-3 d·wk-1; 4 to 5 d·wk-1; and 6-7 d·wk-1. After calculating total metabolic equivalent task-hours per week (MET·h·wk-1), we created eight categories of MET-hours per week (0, 0.1-4.9, 5.0-9.9, 10.0-14.9, 15.0-19.9, 20.0-24.9, 25.0-29.9, and ≥30.0). Multivariate Cox proportional hazard analyses were performed. Results A reverse J-shaped risk curve was observed, with the lowest mortality risk in the participants exercising 4 to 5 d·wk-1 (reference). Participants who did not exercise at all and those who exercised with a PA frequency of 1 to 3 d·wk-1 or 6 to 7 d·wk-1 showed a significantly increased mortality risk compared with the reference group. When we repeated the Cox analysis among the 8 MET·h·wk-1 categories with the participants reporting 20.0 to 24.9 MET·h·wk-1 of PA as the reference group, we found that those with physical inactivity and 25.0-29.9 or ≥30.0 MET·h·wk-1 of PA showed a higher mortality risk than the reference group. These relationships were persistently observed after adjustment for confounders. Conclusions An appropriate amount of regular exercise in each specific type of PA was associated with the lowest risk of mortality. The inactive participants showed an increased mortality risk, and daily PA did not show any additional benefit in the mortality risk.

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