This paper presents MultiHype, a novel architecture that supports multiple hypervisors (or virtual machine monitors) on a single physical platform by leveraging many-core based cloud-on-chip architecture. A MultiHype platform consists of a control plane and multiple hypervisors created on-demand, each can further create multiple guest virtual machines. Supported at architectural level, a single platform using MultiHype can behave as a distributed system with each hypervisor and its virtual machines running independently and concurrently. As a direct consequence, vulnerabilities of one hypervisor or its guest virtual machine can be confined within its own domain, which makes the platform more resilient to malicious attacks and failures in a cloud environment. Towards defending against resource exhaustion attacks, MultiHype further implements a new cache eviction policy and memory management scheme for preventing resource monopolization on shared cache, and defending against denial of resource exploits on physical memory resource launched from malicious virtual machines on shared platform. We use Bochs emulator and cycle based x86 simulation to evaluate the effectiveness and performance of MultiHype.