Are sensory TRP channels biological alarms for lipid peroxidation?

Seung In Choi, Sungjae Yoo, Ji Yeon Lim, Sun Wook Hwang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Oxidative stress induces numerous biological problems. Lipid oxidation and peroxidation appear to be important steps by which exposure to oxidative stress leads the body to a disease state. For its protection, the body has evolved to respond to and eliminate peroxidation products through the acquisition of binding proteins, reducing and conjugating enzymes, and excretion systems. During the past decade, researchers have identified a group of ion channel molecules that are activated by oxidized lipids: transient receptor potential (TRP) channels expressed in sensory neurons. These ion channels are fundamentally detectors and signal converters for body-damaging environments such as heat and cold temperatures, mechanical attacks, and potentially toxic substances. When messages initiated by TRP activation arrive at the brain, we perceive pain, which results in our preparing defensive responses. Excessive activation of the sensory neuronal TRP channels upon prolonged stimulations sometimes deteriorates the inflammatory state of damaged tissues by promoting neuropeptide release from expresser neurons. These same paradigms may also work for pathologic changes in the internal lipid environment upon exposure to oxidative stress. Here, we provide an overview of the role of TRP channels and oxidized lipid connections during abnormally increased oxidative signaling, and consider the sensory mechanism of TRP detection as an alert system.

Original languageEnglish
Pages (from-to)16430-16457
Number of pages28
JournalInternational Journal of Molecular Sciences
Volume15
Issue number9
DOIs
Publication statusPublished - 2014 Sep 17

Fingerprint

Transient Receptor Potential Channels
warning systems
Sensory Receptor Cells
Lipids
Lipid Peroxidation
Oxidative stress
lipids
Oxidative Stress
Ion Channels
Neurons
neurons
Poisons
Chemical activation
Neuropeptides
activation
Carrier Proteins
Hot Temperature
excretion
Research Personnel
pain

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

Cite this

Are sensory TRP channels biological alarms for lipid peroxidation? / Choi, Seung In; Yoo, Sungjae; Lim, Ji Yeon; Hwang, Sun Wook.

In: International Journal of Molecular Sciences, Vol. 15, No. 9, 17.09.2014, p. 16430-16457.

Research output: Contribution to journalArticle

Choi, Seung In ; Yoo, Sungjae ; Lim, Ji Yeon ; Hwang, Sun Wook. / Are sensory TRP channels biological alarms for lipid peroxidation?. In: International Journal of Molecular Sciences. 2014 ; Vol. 15, No. 9. pp. 16430-16457.
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